full name
kinase insert domain receptor

synonyms
CD309, FLK1, VEGFR, VEGFR2, KDR, ENSG00000128052

HGNC
HGNC:6307

Entrez Gene
Gene:3791

ENSEMBL
ENSG00000128052

location
chr: 4
start: 55944426
stop: 55991762
strand: -

OMIM
OMIM:191306: KDR (Autosomal dominant inheritance)
OMIM:602089: Hemangioma, capillary infantile, somatic
OMIM:602089: {Hemangioma, capillary infantile, susceptibility to}

transcripts
NM_002253.2

pathways
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Cytokine-cytokine receptor interaction [NCBI:83051] [KEGG:hsa04060] [PUBMED:11071910] [PUBMED:12072446] [PUBMED:7791754] [PUBMED:15032600] [PUBMED:12651226] [PUBMED:11252892] [PUBMED:11796220] [PUBMED:11312110] [PUBMED:9862719] [PUBMED:12421671] [PUBMED:12039028] [PUBMED:9759503] [PUBMED:9395284] [PUBMED:11166270] [PUBMED:10714678] [PUBMED:12651221]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
EGFR tyrosine kinase inhibitor resistance [NCBI:1404798] [KEGG:hsa01521] [PUBMED:16843264] [PUBMED:23401451] [PUBMED:20966921] [PUBMED:24307395] [PUBMED:22956644] [PUBMED:25232485] [PUBMED:24493829] [PUBMED:23071030] [PUBMED:18483355] [PUBMED:24202392] [PUBMED:19632948] [PUBMED:23361103] [PUBMED:26579470] [PUBMED:22970367] [PUBMED:23358468] [PUBMED:17554333] [PUBMED:25337673] [PUBMED:22474259] [PUBMED:20551942]
EPH-Ephrin signaling [NCBI:1270330] [REACTOME:R-HSA-2682334] [PUBMED:18281458] [PUBMED:22120527]
EPHA-mediated growth cone collapse [NCBI:1270331] [REACTOME:R-HSA-3928663] [PUBMED:17300218] [PUBMED:15093606] [PUBMED:15469835] [PUBMED:15848799] [PUBMED:15928710] [PUBMED:11336673]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
Extracellular matrix organization [NCBI:1270244] [REACTOME:R-HSA-1474244] [PUBMED:21123617] [PUBMED:21917992] [PUBMED:12845610]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
Focal adhesion [NCBI:83067] [KEGG:hsa04510] [PUBMED:10698680] [PUBMED:15459662] [PUBMED:14756624] [PUBMED:11573199] [PUBMED:12640026] [PUBMED:15179030] [PUBMED:15108811] [PUBMED:15053919] [PUBMED:11082269] [PUBMED:15034601] [PUBMED:12235283] [PUBMED:14519391] [PUBMED:11146675] [PUBMED:11229600] [PUBMED:15688067] [PUBMED:14744429] [PUBMED:11882383]
HIF-2-alpha transcription factor network [NCBI:137956] [Pathway Interaction Database:hif2pathway] [PUBMED:10671489] [PUBMED:11983697] [PUBMED:11823643] [PUBMED:15039136] [PUBMED:19352007] [PUBMED:18356544] [PUBMED:17097563] [PUBMED:16740701] [PUBMED:19541651] [PUBMED:17873906] [PUBMED:12080085] [PUBMED:11292862] [PUBMED:16510872] [PUBMED:19498162] [PUBMED:10353251] [PUBMED:18625704] [PUBMED:15247232] [PUBMED:9079689] [PUBMED:19204094] [PUBMED:17322295] [PUBMED:17804822] [PUBMED:9113979] [PUBMED:12464608] [PUBMED:18434321] [PUBMED:15592504] [PUBMED:10878807] [PUBMED:17324924] [PUBMED:15192019] [PUBMED:9000051] [PUBMED:16611993] [PUBMED:10823831]
Integrin cell surface interactions [NCBI:1270260] [REACTOME:R-HSA-216083] [PUBMED:10215583] [PUBMED:15147720] [PUBMED:12231361] [PUBMED:8866399] [PUBMED:19273203]
Integrins in angiogenesis [NCBI:137999] [Pathway Interaction Database:avb3_integrin_pathway] [PUBMED:10837460] [PUBMED:9182576] [PUBMED:12642872] [PUBMED:15711558] [PUBMED:10037797] [PUBMED:10196194] [PUBMED:11877390] [PUBMED:16418218] [PUBMED:16600665] [PUBMED:16982628] [PUBMED:15479743] [PUBMED:16720645] [PUBMED:11684710] [PUBMED:10821695] [PUBMED:12237112] [PUBMED:12750158] [PUBMED:11551924] [PUBMED:8794870] [PUBMED:10022831] [PUBMED:15187087] [PUBMED:16195423] [PUBMED:16760434] [PUBMED:12682293] [PUBMED:9420328] [PUBMED:15247219] [PUBMED:9490736] [PUBMED:11313365]
Neurophilin interactions with VEGF and VEGFR [NCBI:1269486] [REACTOME:R-HSA-194306] [PUBMED:12613545]
Notch-mediated HES/HEY network [NCBI:169347] [Pathway Interaction Database:hes_heypathway] [PUBMED:15546612] [PUBMED:11038350] [PUBMED:12065598] [PUBMED:11741889] [PUBMED:10851137] [PUBMED:10205173] [PUBMED:10747963] [PUBMED:10913198] [PUBMED:11101851] [PUBMED:16201968] [PUBMED:12488457] [PUBMED:12370315] [PUBMED:19116245] [PUBMED:16025100] [PUBMED:11486044] [PUBMED:15607978] [PUBMED:15467735] [PUBMED:14739937] [PUBMED:9694793] [PUBMED:8749394] [PUBMED:16782059] [PUBMED:12972610] [PUBMED:17392792] [PUBMED:11334435] [PUBMED:11486045] [PUBMED:16753023] [PUBMED:15485867] [PUBMED:15866158] [PUBMED:16199874] [PUBMED:12374742] [PUBMED:9570950] [PUBMED:10964718] [PUBMED:16682003] [PUBMED:16287852] [PUBMED:10692439] [PUBMED:11095750] [PUBMED:11287612] [PUBMED:15314183] [PUBMED:15156153] [PUBMED:15684393] [PUBMED:7566092] [PUBMED:11604511] [PUBMED:9819403] [PUBMED:15563463] [PUBMED:15870295]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
Rap1 signaling pathway [NCBI:868086] [KEGG:hsa04015] [PUBMED:17624944] [PUBMED:12351703] [PUBMED:10579920] [PUBMED:19159611] [PUBMED:18363565] [PUBMED:12765839] [PUBMED:12508104] [PUBMED:11331911] [PUBMED:17182900] [PUBMED:15803158] [PUBMED:19615876] [PUBMED:21402149] [PUBMED:17624948] [PUBMED:17383543] [PUBMED:14607972] [PUBMED:15780587] [PUBMED:19710505]
Ras signaling pathway [NCBI:868085] [KEGG:hsa04014] [PUBMED:23506953] [PUBMED:18437264] [PUBMED:15062121] [PUBMED:22189424] [PUBMED:22233291] [PUBMED:12778136] [PUBMED:11313946] [PUBMED:17428555] [PUBMED:19091743] [PUBMED:18568040] [PUBMED:20420946] [PUBMED:12217381] [PUBMED:14663478] [PUBMED:21686117] [PUBMED:12642680] [PUBMED:21196257] [PUBMED:16869784] [PUBMED:21111786] [PUBMED:16966426] [PUBMED:10712923] [PUBMED:22020205] [PUBMED:17384584] [PUBMED:15572660] [PUBMED:18413813]
S1P1 pathway [NCBI:137937] [Pathway Interaction Database:s1p_s1p1_pathway] [PUBMED:10198065] [PUBMED:12782628] [PUBMED:15750791] [PUBMED:11741892] [PUBMED:12963813] [PUBMED:11150298] [PUBMED:10463951] [PUBMED:9660876] [PUBMED:12087059] [PUBMED:12796504] [PUBMED:12175535] [PUBMED:11709084] [PUBMED:17050692] [PUBMED:12586615] [PUBMED:17257496]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Signaling events mediated by TCPTP [NCBI:169350] [Pathway Interaction Database:tcptp_pathway] [PUBMED:12612081] [PUBMED:18716132] [PUBMED:19171783] [PUBMED:9488479] [PUBMED:15592458] [PUBMED:9261175] [PUBMED:16431927] [PUBMED:15632081] [PUBMED:12359225] [PUBMED:12138178] [PUBMED:7593185] [PUBMED:18840653] [PUBMED:15696169] [PUBMED:18691551] [PUBMED:20484139] [PUBMED:11773439] [PUBMED:16595549] [PUBMED:18948751] [PUBMED:16971512] [PUBMED:12171910] [PUBMED:18819921] [PUBMED:15192089] [PUBMED:17210636] [PUBMED:10488121] [PUBMED:16705167] [PUBMED:14966296] [PUBMED:11909529] [PUBMED:11479308]
Signaling events mediated by VEGFR1 and VEGFR2 [NCBI:137940] [Pathway Interaction Database:vegfr1_2_pathway] [PUBMED:9398617] [PUBMED:9405464] [PUBMED:11494124] [PUBMED:12963813] [PUBMED:11756651] [PUBMED:10744763] [PUBMED:15060076] [PUBMED:9600074] [PUBMED:10376603] [PUBMED:11425855] [PUBMED:16337972] [PUBMED:12154000] [PUBMED:11978735] [PUBMED:10692392] [PUBMED:16763158] [PUBMED:10361126] [PUBMED:10748121] [PUBMED:12598525] [PUBMED:15026417] [PUBMED:11948691] [PUBMED:16966330] [PUBMED:16835467] [PUBMED:10409677] [PUBMED:10908731] [PUBMED:8903320] [PUBMED:15962004] [PUBMED:16633338] [PUBMED:11387210] [PUBMED:16839566] [PUBMED:11312102] [PUBMED:10207622] [PUBMED:16787925] [PUBMED:12171920] [PUBMED:12509223] [PUBMED:16760434] [PUBMED:14724572] [PUBMED:11704645] [PUBMED:12821150] [PUBMED:12881528] [PUBMED:9790910] [PUBMED:10376602] [PUBMED:15247219] [PUBMED:11333271] [PUBMED:12214271] [PUBMED:9804796] [PUBMED:11986311] [PUBMED:9182576] [PUBMED:15217908] [PUBMED:10749680] [PUBMED:16763549]
VEGF binds to VEGFR leading to receptor dimerization [NCBI:1269482] [REACTOME:R-HSA-195399] [PUBMED:13678960] [PUBMED:16633338] [PUBMED:16835467]
VEGF ligand-receptor interactions [NCBI:1269481] [REACTOME:R-HSA-194313] [PUBMED:16633338] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
VEGF signaling pathway [NCBI:83066] [KEGG:hsa04370] [PUBMED:11741095] [PUBMED:16104843] [PUBMED:14641020] [PUBMED:15338053] [PUBMED:14724572] [PUBMED:12391145] [PUBMED:13678960] [PUBMED:15602010]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:17344076] [PUBMED:16633338] [PUBMED:19230644] [PUBMED:13678960]
VEGFR2 mediated cell proliferation [NCBI:1269485] [REACTOME:R-HSA-5218921] [PUBMED:22866201] [PUBMED:22180219] [PUBMED:22762016]