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Genes
SPP1
Gene - SPP1
full name
secreted phosphoprotein 1
synonyms
BNSP, BSPI, ETA-1, OPN, SPP1, ENSG00000118785
HGNC
HGNC:11255
Entrez Gene
Gene:6696
ENSEMBL
ENSG00000118785
location
chr: 4
start: 88896802
stop: 88904563
strand: +
transcripts
NM_001251830.1
NM_001040058.1
NM_000582.2
NM_001040060.1
NM_001251829.1
pathways
Apelin signaling pathway
[NCBI:1492886]
[KEGG:hsa04371]
[PUBMED:23973488]
[PUBMED:16182514]
[PUBMED:21725702]
[PUBMED:22842084]
[PUBMED:27825851]
[PUBMED:27650065]
[PUBMED:22140623]
[PUBMED:23943882]
[PUBMED:26944568]
[PUBMED:24055369]
[PUBMED:26385179]
[PUBMED:26143239]
[PUBMED:22028387]
[PUBMED:26254105]
[PUBMED:26756969]
[PUBMED:22995518]
[PUBMED:27979574]
[PUBMED:23924696]
[PUBMED:21464822]
[PUBMED:25914650]
[PUBMED:24990699]
[PUBMED:26607438]
[PUBMED:25164121]
[PUBMED:25275559]
[PUBMED:25139773]
[PUBMED:25931124]
[PUBMED:19093215]
[PUBMED:20539939]
[PUBMED:25652330]
[PUBMED:18272138]
[PUBMED:23603510]
Degradation of the extracellular matrix
[NCBI:1270257]
[REACTOME:R-HSA-1474228]
[PUBMED:21917992]
Direct p53 effectors
[NCBI:137939]
[Pathway Interaction Database:p53downstreampathway]
[PUBMED:7479001]
[PUBMED:19626115]
[PUBMED:10692390]
[PUBMED:15289308]
[PUBMED:14688482]
[PUBMED:16301995]
[PUBMED:11850816]
[PUBMED:12370809]
[PUBMED:16260627]
[PUBMED:15186775]
[PUBMED:15580302]
[PUBMED:10748162]
[PUBMED:10919640]
[PUBMED:19011621]
[PUBMED:12438652]
[PUBMED:11559530]
[PUBMED:11641774]
[PUBMED:11971958]
[PUBMED:9659898]
[PUBMED:9343394]
[PUBMED:10716435]
[PUBMED:17146433]
[PUBMED:17719542]
[PUBMED:17938176]
[PUBMED:17409421]
[PUBMED:11032029]
[PUBMED:15781865]
[PUBMED:11463392]
[PUBMED:9736732]
[PUBMED:17268548]
[PUBMED:8570655]
[PUBMED:18046411]
[PUBMED:12944906]
[PUBMED:16249378]
[PUBMED:15273740]
[PUBMED:15598651]
[PUBMED:10618379]
[PUBMED:15958553]
[PUBMED:17189187]
[PUBMED:17145718]
[PUBMED:11988847]
[PUBMED:8119988]
[PUBMED:12089322]
[PUBMED:16286009]
[PUBMED:12890671]
[PUBMED:12402042]
[PUBMED:10618714]
[PUBMED:14730312]
[PUBMED:12857899]
[PUBMED:14963330]
[PUBMED:11278953]
[PUBMED:11973653]
[PUBMED:12692263]
[PUBMED:10984493]
[PUBMED:10640990]
[PUBMED:11545734]
[PUBMED:16151013]
[PUBMED:12372430]
[PUBMED:16651407]
[PUBMED:9891062]
[PUBMED:12606722]
[PUBMED:12453409]
[PUBMED:15377670]
[PUBMED:12667443]
[PUBMED:17707234]
[PUBMED:9920903]
[PUBMED:14992722]
[PUBMED:15790310]
[PUBMED:15831478]
[PUBMED:11314010]
[PUBMED:10329733]
[PUBMED:17264218]
[PUBMED:11511362]
[PUBMED:11919562]
[PUBMED:11814693]
[PUBMED:17554199]
[PUBMED:18250150]
[PUBMED:10518217]
[PUBMED:10891498]
[PUBMED:10973264]
[PUBMED:15077116]
[PUBMED:16230375]
[PUBMED:18485870]
[PUBMED:7796420]
[PUBMED:15710382]
[PUBMED:17409411]
[PUBMED:8319905]
[PUBMED:10684646]
[PUBMED:7566179]
[PUBMED:8887630]
[PUBMED:11807984]
[PUBMED:9841917]
[PUBMED:12654245]
[PUBMED:9023107]
[PUBMED:15103385]
[PUBMED:11684014]
[PUBMED:17110336]
[PUBMED:11278253]
[PUBMED:14576823]
[PUBMED:8418500]
[PUBMED:11350971]
[PUBMED:11840333]
[PUBMED:7651818]
[PUBMED:7651386]
[PUBMED:15378026]
[PUBMED:15607964]
[PUBMED:11279192]
[PUBMED:10777218]
[PUBMED:15334053]
[PUBMED:12138177]
[PUBMED:9619826]
[PUBMED:16278683]
[PUBMED:17189186]
[PUBMED:16140933]
[PUBMED:10094469]
[PUBMED:9926927]
[PUBMED:17719541]
[PUBMED:15735003]
[PUBMED:12853982]
[PUBMED:14707288]
[PUBMED:10777207]
ECM-receptor interaction
[NCBI:83068]
[KEGG:hsa04512]
[PUBMED:7698997]
[PUBMED:15381249]
[PUBMED:12796473]
[PUBMED:11331578]
[PUBMED:15036264]
[PUBMED:12125070]
[PUBMED:12736199]
[PUBMED:15229478]
[PUBMED:11572082]
[PUBMED:10617638]
[PUBMED:12845610]
[PUBMED:12921709]
Extracellular matrix organization
[NCBI:1270244]
[REACTOME:R-HSA-1474244]
[PUBMED:21123617]
[PUBMED:21917992]
[PUBMED:12845610]
FGF signaling pathway
[NCBI:137989]
[Pathway Interaction Database:fgf_pathway]
[PUBMED:12419216]
[PUBMED:16775459]
[PUBMED:1656221]
[PUBMED:16857743]
[PUBMED:8707855]
[PUBMED:17545628]
[PUBMED:17623664]
[PUBMED:16893902]
[PUBMED:15105428]
[PUBMED:16436388]
[PUBMED:12370824]
[PUBMED:9707175]
[PUBMED:1380001]
[PUBMED:15569927]
[PUBMED:11241670]
[PUBMED:11433297]
[PUBMED:16709412]
[PUBMED:12815057]
[PUBMED:14966081]
[PUBMED:17086194]
[PUBMED:17311277]
[PUBMED:14534538]
[PUBMED:12398894]
[PUBMED:8940113]
[PUBMED:17266935]
[PUBMED:10652257]
[PUBMED:12604616]
[PUBMED:14666721]
[PUBMED:9045692]
[PUBMED:15509650]
[PUBMED:11353842]
[PUBMED:12791257]
[PUBMED:15564375]
[PUBMED:12529371]
[PUBMED:17409417]
[PUBMED:17005551]
[PUBMED:12815619]
[PUBMED:11997436]
[PUBMED:12110689]
[PUBMED:17627937]
Focal adhesion
[NCBI:83067]
[KEGG:hsa04510]
[PUBMED:10698680]
[PUBMED:15459662]
[PUBMED:14756624]
[PUBMED:11573199]
[PUBMED:12640026]
[PUBMED:15179030]
[PUBMED:15108811]
[PUBMED:15053919]
[PUBMED:11082269]
[PUBMED:15034601]
[PUBMED:12235283]
[PUBMED:14519391]
[PUBMED:11146675]
[PUBMED:11229600]
[PUBMED:15688067]
[PUBMED:14744429]
[PUBMED:11882383]
Integrin cell surface interactions
[NCBI:1270260]
[REACTOME:R-HSA-216083]
[PUBMED:10215583]
[PUBMED:15147720]
[PUBMED:12231361]
[PUBMED:8866399]
[PUBMED:19273203]
Integrins in angiogenesis
[NCBI:137999]
[Pathway Interaction Database:avb3_integrin_pathway]
[PUBMED:10837460]
[PUBMED:9182576]
[PUBMED:12642872]
[PUBMED:15711558]
[PUBMED:10037797]
[PUBMED:10196194]
[PUBMED:11877390]
[PUBMED:16418218]
[PUBMED:16600665]
[PUBMED:16982628]
[PUBMED:15479743]
[PUBMED:16720645]
[PUBMED:11684710]
[PUBMED:10821695]
[PUBMED:12237112]
[PUBMED:12750158]
[PUBMED:11551924]
[PUBMED:8794870]
[PUBMED:10022831]
[PUBMED:15187087]
[PUBMED:16195423]
[PUBMED:16760434]
[PUBMED:12682293]
[PUBMED:9420328]
[PUBMED:15247219]
[PUBMED:9490736]
[PUBMED:11313365]
Osteopontin-mediated events
[NCBI:137960]
[Pathway Interaction Database:avb3_opn_pathway]
[PUBMED:9727056]
[PUBMED:9585425]
[PUBMED:16888388]
[PUBMED:16474180]
[PUBMED:15757900]
[PUBMED:9682033]
[PUBMED:12529435]
[PUBMED:15142256]
[PUBMED:14624447]
[PUBMED:15711558]
[PUBMED:9988732]
[PUBMED:12730217]
[PUBMED:11600576]
[PUBMED:8744948]
[PUBMED:16691505]
[PUBMED:11940607]
[PUBMED:16006560]
[PUBMED:10766830]
[PUBMED:10559185]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Toll-like receptor signaling pathway
[NCBI:83076]
[KEGG:hsa04620]
[PUBMED:16924467]
[PUBMED:17395581]
[PUBMED:17637696]
[PUBMED:12734364]
[PUBMED:17507094]
[PUBMED:14698224]
[PUBMED:11101877]
[PUBMED:16497588]
[PUBMED:14751764]
[PUBMED:17275323]
[PUBMED:17457343]
[PUBMED:16932750]