full name
MPL proto-oncogene, thrombopoietin receptor

synonyms
C-MPL, CD110, MPLV, THCYT2, TPOR, MPL, ENSG00000117400

HGNC
HGNC:7217

Entrez Gene
Gene:4352

ENSEMBL
ENSG00000117400

location
chr: 1
start: 43803475
stop: 43820135
strand: +

OMIM
OMIM:159530: MPL (Autosomal dominant inheritance)
OMIM:254450: Myelofibrosis with myeloid metaplasia, somatic
OMIM:601977: Thrombocythemia 2
OMIM:604498: Thrombocytopenia, congenital amegakaryocytic

transcripts
NM_005373.2

pathways
Cytokine-cytokine receptor interaction [NCBI:83051] [KEGG:hsa04060] [PUBMED:11071910] [PUBMED:12072446] [PUBMED:7791754] [PUBMED:15032600] [PUBMED:12651226] [PUBMED:11252892] [PUBMED:11796220] [PUBMED:11312110] [PUBMED:9862719] [PUBMED:12421671] [PUBMED:12039028] [PUBMED:9759503] [PUBMED:9395284] [PUBMED:11166270] [PUBMED:10714678] [PUBMED:12651221]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Jak-STAT signaling pathway [NCBI:83077] [KEGG:hsa04630] [PUBMED:21034406] [PUBMED:22339650] [PUBMED:16204702] [PUBMED:25587654] [PUBMED:24069565] [PUBMED:22383755] [PUBMED:24606160] [PUBMED:10851053] [PUBMED:23735217] [PUBMED:25217450] [PUBMED:21372217]
Platelet Aggregation (Plug Formation) [NCBI:1269358] [REACTOME:R-HSA-76009] [PUBMED:18174460] [PUBMED:17585075]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]