full name
protein phosphatase 3 catalytic subunit alpha
synonyms
CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, PPP3CA, ENSG00000138814
HGNC
HGNC:9314
Entrez Gene
Gene:5530
ENSEMBL
ENSG00000138814
location
chr: 4
start: 101944587
stop: 102268655
strand: -
OMIM
OMIM:114105:
PPP3CA
OMIM:618265:
Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development
OMIM:617711:
Epileptic encephalopathy, infantile or early childhood, 1
transcripts
NM_001130692.1
NM_001130691.1
NM_000944.4
pathways
Alzheimer's disease
[NCBI:83097]
[KEGG:hsa05010]
[PUBMED:18782350]
[PUBMED:18035450]
[PUBMED:15177383]
[PUBMED:10527810]
[PUBMED:15363492]
[PUBMED:16677790]
[PUBMED:15295589]
[PUBMED:17055782]
[PUBMED:15864339]
[PUBMED:15750290]
[PUBMED:18675468]
[PUBMED:15232608]
[PUBMED:9848086]
[PUBMED:11484003]
[PUBMED:10830966]
[PUBMED:16529745]
[PUBMED:17568632]
Amphetamine addiction
[NCBI:547607]
[KEGG:hsa05031]
[PUBMED:16776597]
[PUBMED:18617632]
[PUBMED:16724157]
[PUBMED:19222557]
[PUBMED:14746512]
[PUBMED:18632938]
[PUBMED:8630246]
[PUBMED:14622123]
[PUBMED:21338876]
[PUBMED:8753884]
[PUBMED:10774721]
[PUBMED:14529709]
[PUBMED:17728700]
[PUBMED:21989194]
[PUBMED:16151049]
[PUBMED:18440072]
[PUBMED:19199083]
[PUBMED:10414964]
Amyotrophic lateral sclerosis (ALS)
[NCBI:83099]
[KEGG:hsa05014]
[PUBMED:16026864]
[PUBMED:16924260]
[PUBMED:11513882]
[PUBMED:17015226]
[PUBMED:16723044]
[PUBMED:10970056]
[PUBMED:16909020]
[PUBMED:12531867]
[PUBMED:16713195]
[PUBMED:16603792]
[PUBMED:11870681]
[PUBMED:16050975]
[PUBMED:17409386]
[PUBMED:11239414]
[PUBMED:18519638]
[PUBMED:14569202]
[PUBMED:12728264]
[PUBMED:11715057]
[PUBMED:17566607]
[PUBMED:17434459]
[PUBMED:16909017]
[PUBMED:12595144]
[PUBMED:15310460]
[PUBMED:14739060]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
B cell receptor signaling pathway
[NCBI:83081]
[KEGG:hsa04662]
[PUBMED:15626471]
[PUBMED:12119152]
[PUBMED:15886119]
[PUBMED:12461567]
[PUBMED:9697839]
[PUBMED:15752555]
[PUBMED:11163197]
[PUBMED:18086859]
[PUBMED:15364057]
[PUBMED:15457440]
[PUBMED:15322145]
[PUBMED:15771577]
[PUBMED:12033741]
[PUBMED:15886112]
[PUBMED:10358768]
BCR signaling pathway
[NCBI:138058]
[Pathway Interaction Database:bcr_5pathway]
[PUBMED:7687428]
[PUBMED:16200195]
[PUBMED:12730099]
[PUBMED:10770799]
[PUBMED:14563325]
[PUBMED:9763608]
[PUBMED:15541657]
[PUBMED:11781242]
[PUBMED:11102801]
[PUBMED:9586640]
[PUBMED:11279148]
[PUBMED:7499277]
[PUBMED:7542197]
[PUBMED:9820480]
[PUBMED:9221755]
[PUBMED:11909947]
[PUBMED:9360945]
[PUBMED:9058799]
[PUBMED:10339589]
[PUBMED:11226282]
[PUBMED:9271416]
[PUBMED:9620684]
[PUBMED:11163197]
[PUBMED:10820378]
[PUBMED:11356195]
[PUBMED:11080163]
[PUBMED:10755621]
[PUBMED:7717978]
[PUBMED:7618087]
[PUBMED:11577348]
[PUBMED:1279802]
[PUBMED:10640270]
[PUBMED:11356834]
[PUBMED:12867038]
[PUBMED:12780340]
[PUBMED:10430908]
[PUBMED:7528218]
Beta-catenin independent WNT signaling
[NCBI:1269610]
[REACTOME:R-HSA-3858494]
[PUBMED:22935904]
[PUBMED:21903638]
[PUBMED:23256519]
[PUBMED:8065359]
[PUBMED:7739543]
[PUBMED:23140633]
C-MYB transcription factor network
[NCBI:138073]
[Pathway Interaction Database:cmyb_pathway]
[PUBMED:17152050]
[PUBMED:1944282]
[PUBMED:7964503]
[PUBMED:8598284]
[PUBMED:15608679]
[PUBMED:10619021]
[PUBMED:2233716]
[PUBMED:9244354]
[PUBMED:8654374]
[PUBMED:10590070]
[PUBMED:17587615]
[PUBMED:12424255]
[PUBMED:1679531]
[PUBMED:17077080]
[PUBMED:8946914]
[PUBMED:16055116]
[PUBMED:11259163]
[PUBMED:9659917]
[PUBMED:9135152]
[PUBMED:7721782]
[PUBMED:11290610]
[PUBMED:12244173]
[PUBMED:11792321]
[PUBMED:17242210]
[PUBMED:10722757]
[PUBMED:8264615]
[PUBMED:15687240]
[PUBMED:14761981]
[PUBMED:10542314]
[PUBMED:12673198]
[PUBMED:11779867]
[PUBMED:8756344]
[PUBMED:11427482]
[PUBMED:9809063]
[PUBMED:10523863]
[PUBMED:11094072]
[PUBMED:15356292]
[PUBMED:11781241]
[PUBMED:15778089]
[PUBMED:9096387]
[PUBMED:17931383]
[PUBMED:14576818]
[PUBMED:11259170]
[PUBMED:8491193]
[PUBMED:11581319]
[PUBMED:10644988]
[PUBMED:7565722]
[PUBMED:9490676]
[PUBMED:9244356]
[PUBMED:17641686]
[PUBMED:16407849]
[PUBMED:1594249]
[PUBMED:17822556]
[PUBMED:15867358]
[PUBMED:17959653]
[PUBMED:7509358]
[PUBMED:11287612]
[PUBMED:15082531]
[PUBMED:10766162]
[PUBMED:8756629]
[PUBMED:11115410]
[PUBMED:7684005]
[PUBMED:9566892]
C-type lectin receptors (CLRs)
[NCBI:1269303]
[REACTOME:R-HSA-5621481]
[PUBMED:19521399]
[PUBMED:24330199]
CLEC7A (Dectin-1) induces NFAT activation
[NCBI:1269305]
[REACTOME:R-HSA-5607763]
[PUBMED:17312158]
[PUBMED:22611159]
[PUBMED:21728173]
CLEC7A (Dectin-1) signaling
[NCBI:1269304]
[REACTOME:R-HSA-5607764]
[PUBMED:12719478]
[PUBMED:19223162]
Ca2+ pathway
[NCBI:1269615]
[REACTOME:R-HSA-4086398]
[PUBMED:21903638]
[PUBMED:21181886]
[PUBMED:16099039]
Calcium signaling pathway
[NCBI:83050]
[KEGG:hsa04020]
[PUBMED:11080247]
[PUBMED:14572802]
[PUBMED:11413485]
[PUBMED:22129055]
[PUBMED:10508738]
[PUBMED:15000521]
[PUBMED:9235901]
[PUBMED:7861177]
[PUBMED:9149541]
[PUBMED:14517314]
[PUBMED:15111104]
[PUBMED:11698232]
[PUBMED:10331643]
[PUBMED:12838335]
[PUBMED:8125957]
[PUBMED:19172794]
[PUBMED:10997573]
[PUBMED:21338471]
[PUBMED:11299192]
[PUBMED:22002090]
[PUBMED:12972622]
DARPP-32 events
[NCBI:1269591]
[REACTOME:R-HSA-180024]
[PUBMED:14744247]
[PUBMED:2908293]
Dopaminergic synapse
[NCBI:469199]
[KEGG:hsa04728]
[PUBMED:20727368]
[PUBMED:10433257]
[PUBMED:17408758]
[PUBMED:15292232]
[PUBMED:9457173]
[PUBMED:17349698]
[PUBMED:15521361]
[PUBMED:18353279]
[PUBMED:21303898]
[PUBMED:19251795]
[PUBMED:15381316]
[PUBMED:15590733]
[PUBMED:20224735]
[PUBMED:19138563]
[PUBMED:12967774]
FCERI mediated Ca+2 mobilization
[NCBI:1269300]
[REACTOME:R-HSA-2871809]
[PUBMED:17336609]
[PUBMED:10807788]
[PUBMED:1309940]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Glucagon signaling pathway
[NCBI:1144996]
[KEGG:hsa04922]
[PUBMED:20735177]
[PUBMED:19912989]
[PUBMED:21941300]
[PUBMED:22249520]
[PUBMED:12626323]
[PUBMED:16601267]
[PUBMED:18669612]
[PUBMED:24393785]
[PUBMED:21346730]
[PUBMED:22550228]
[PUBMED:16479585]
[PUBMED:24692138]
[PUBMED:22495310]
[PUBMED:22796337]
[PUBMED:22004992]
[PUBMED:24238363]
[PUBMED:22503562]
Glutamatergic synapse
[NCBI:213818]
[KEGG:hsa04724]
[PUBMED:10481192]
[PUBMED:11561058]
[PUBMED:18425072]
[PUBMED:17706608]
[PUBMED:20055706]
[PUBMED:19112153]
[PUBMED:17663464]
[PUBMED:19110202]
[PUBMED:19559598]
[PUBMED:9665875]
[PUBMED:11672421]
[PUBMED:18464791]
[PUBMED:12399578]
[PUBMED:14684436]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Long-term potentiation
[NCBI:83085]
[KEGG:hsa04720]
[PUBMED:9697848]
[PUBMED:15652868]
[PUBMED:15803158]
[PUBMED:11378299]
[PUBMED:10652548]
[PUBMED:15857686]
[PUBMED:14715912]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
Natural killer cell mediated cytotoxicity
[NCBI:83079]
[KEGG:hsa04650]
[PUBMED:12530970]
[PUBMED:15567854]
[PUBMED:8942070]
[PUBMED:11905813]
[PUBMED:9143705]
[PUBMED:9862693]
[PUBMED:11895890]
[PUBMED:12205470]
[PUBMED:11836514]
[PUBMED:15607806]
[PUBMED:16002670]
[PUBMED:15618404]
[PUBMED:11390470]
[PUBMED:11062493]
[PUBMED:14710949]
[PUBMED:12752668]
[PUBMED:15607802]
[PUBMED:16109839]
[PUBMED:12766758]
[PUBMED:16177799]
Oocyte meiosis
[NCBI:126909]
[KEGG:hsa04114]
[PUBMED:16760654]
[PUBMED:17480229]
[PUBMED:15136768]
[PUBMED:18946022]
[PUBMED:18598214]
[PUBMED:16518630]
[PUBMED:18631137]
[PUBMED:15182704]
[PUBMED:15182701]
[PUBMED:16554437]
[PUBMED:14691134]
[PUBMED:18550795]
[PUBMED:18096427]
[PUBMED:14517314]
[PUBMED:18311174]
Opioid Signalling
[NCBI:1269584]
[REACTOME:R-HSA-111885]
[PUBMED:9422713]
[PUBMED:9218123]
[PUBMED:16612131]
Osteoclast differentiation
[NCBI:193147]
[KEGG:hsa04380]
[PUBMED:17633024]
[PUBMED:18382763]
[PUBMED:18329366]
[PUBMED:17869613]
[PUBMED:18722561]
[PUBMED:15122243]
[PUBMED:20703218]
[PUBMED:12748652]
[PUBMED:12110142]
[PUBMED:19585227]
[PUBMED:15546140]
[PUBMED:16184196]
[PUBMED:15817678]
[PUBMED:20392226]
[PUBMED:16313349]
[PUBMED:16313342]
[PUBMED:17380158]
[PUBMED:18451259]
Oxytocin signaling pathway
[NCBI:952859]
[KEGG:hsa04921]
[PUBMED:23356278]
[PUBMED:9219843]
[PUBMED:20626426]
[PUBMED:18555543]
[PUBMED:22190926]
[PUBMED:21981277]
[PUBMED:9575824]
[PUBMED:22227279]
[PUBMED:19840865]
[PUBMED:11861513]
[PUBMED:9326674]
[PUBMED:12433531]
[PUBMED:18655881]
[PUBMED:23335873]
[PUBMED:22902539]
[PUBMED:16156781]
[PUBMED:20141572]
[PUBMED:14715914]
[PUBMED:12009385]
[PUBMED:16787565]
[PUBMED:16966388]
Renin secretion
[NCBI:1222951]
[KEGG:hsa04924]
[PUBMED:24944035]
[PUBMED:22733355]
[PUBMED:20936939]
[PUBMED:12949225]
[PUBMED:17360952]
[PUBMED:17928544]
[PUBMED:19948673]
[PUBMED:12388321]
[PUBMED:15283749]
[PUBMED:22237158]
[PUBMED:22258323]
[PUBMED:9882634]
[PUBMED:20393195]
[PUBMED:22124804]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Wnt
[NCBI:1269594]
[REACTOME:R-HSA-195721]
[PUBMED:19530173]
[PUBMED:23256519]
[PUBMED:22952392]
[PUBMED:19204114]
[PUBMED:19365405]
[PUBMED:19619488]
[PUBMED:17143292]
[PUBMED:17230199]
[PUBMED:18710302]
[PUBMED:16099039]
[PUBMED:20576942]
[PUBMED:10858654]
[PUBMED:12967557]
T cell receptor signaling pathway
[NCBI:83080]
[KEGG:hsa04660]
[PUBMED:17395537]
[PUBMED:15308211]
[PUBMED:15928679]
[PUBMED:14656980]
[PUBMED:17187070]
[PUBMED:15084594]
[PUBMED:16799472]
[PUBMED:12669022]
[PUBMED:15286727]
[PUBMED:15122199]
[PUBMED:19132916]
[PUBMED:15489916]
[PUBMED:11905831]
[PUBMED:12195013]
[PUBMED:15343367]
[PUBMED:12133805]
[PUBMED:14647476]
[PUBMED:15771581]
[PUBMED:15099566]
[PUBMED:14617194]
[PUBMED:19290929]
[PUBMED:15345216]
Th1 and Th2 cell differentiation
[NCBI:1458885]
[KEGG:hsa04658]
[PUBMED:15819694]
[PUBMED:12171942]
[PUBMED:19165228]
[PUBMED:23336087]
[PUBMED:26044597]
[PUBMED:19151746]
[PUBMED:19362457]
[PUBMED:22044277]
[PUBMED:11752608]
[PUBMED:23405903]
[PUBMED:19375293]
[PUBMED:24113868]
[PUBMED:19151747]
[PUBMED:23624818]
[PUBMED:22566933]
[PUBMED:11121747]
[PUBMED:20969597]
[PUBMED:20065998]
Th17 cell differentiation
[NCBI:1469482]
[KEGG:hsa04659]
[PUBMED:23325835]
[PUBMED:23036716]
[PUBMED:20488727]
[PUBMED:21151104]
[PUBMED:21084214]
[PUBMED:20054607]
[PUBMED:22754770]
[PUBMED:22640807]
[PUBMED:19379825]
[PUBMED:22133865]
[PUBMED:22324470]
[PUBMED:17768419]
[PUBMED:18408735]
[PUBMED:21776333]
[PUBMED:26253381]
[PUBMED:16200068]
[PUBMED:18362914]
[PUBMED:24325586]
[PUBMED:19381306]
[PUBMED:18166487]
Tuberculosis
[NCBI:213780]
[KEGG:hsa05152]
[PUBMED:20199890]
[PUBMED:21274449]
[PUBMED:17359235]
[PUBMED:20415982]
[PUBMED:18541216]
[PUBMED:19369951]
[PUBMED:15083155]
[PUBMED:11378475]
[PUBMED:15228522]
[PUBMED:19634703]
[PUBMED:21274433]
[PUBMED:19563525]
[PUBMED:18407066]
[PUBMED:18288961]
[PUBMED:16200082]
[PUBMED:17785780]
[PUBMED:11932234]
VEGF signaling pathway
[NCBI:83066]
[KEGG:hsa04370]
[PUBMED:11741095]
[PUBMED:16104843]
[PUBMED:14641020]
[PUBMED:15338053]
[PUBMED:14724572]
[PUBMED:12391145]
[PUBMED:13678960]
[PUBMED:15602010]
Wnt signaling pathway
[NCBI:83061]
[KEGG:hsa04310]
[PUBMED:12446114]
[PUBMED:14745971]
[PUBMED:14530294]
[PUBMED:15102436]
[PUBMED:14635791]
[PUBMED:19482104]
[PUBMED:23256519]
[PUBMED:12967557]
[PUBMED:11433294]
[PUBMED:18838381]
cGMP-PKG signaling pathway
[NCBI:983748]
[KEGG:hsa04022]
[PUBMED:18006449]
[PUBMED:9003029]
[PUBMED:18040025]
[PUBMED:19306895]
[PUBMED:21666108]
[PUBMED:12524221]
[PUBMED:16460276]
[PUBMED:20716671]
[PUBMED:22785374]
[PUBMED:11522789]
[PUBMED:16439998]
[PUBMED:16371594]
[PUBMED:20388537]
[PUBMED:18757523]
[PUBMED:16815627]
[PUBMED:23212367]
[PUBMED:21685243]
[PUBMED:20024580]
[PUBMED:15894227]
[PUBMED:22965426]
[PUBMED:17643091]
[PUBMED:19176601]
[PUBMED:19961855]