full name
polo like kinase 4

synonyms
SAK, STK18, PLK4, ENSG00000142731

HGNC
HGNC:11397

Entrez Gene
Gene:10733

ENSEMBL
ENSG00000142731

location
chr: 4
start: 128802016
stop: 128820379
strand: +

OMIM
OMIM:605031: PLK4
OMIM:616171: Microcephaly and chorioretinopathy, autosomal recessive, 2

transcripts
NM_014264.4
NM_001190799.1
NM_001190801.1

pathways
AURKA Activation by TPX2 [NCBI:1383018] [REACTOME:R-HSA-8854518] [PUBMED:14580337] [PUBMED:21147853] [PUBMED:22094468] [PUBMED:21347367]
Anchoring of the basal body to the plasma membrane [NCBI:1268847] [REACTOME:R-HSA-5620912] [PUBMED:21816947] [PUBMED:23747070] [PUBMED:19575670] [PUBMED:13978319] [PUBMED:23348840] [PUBMED:25047614] [PUBMED:20819941] [PUBMED:5661997] [PUBMED:21422230] [PUBMED:24469809] [PUBMED:23530209] [PUBMED:21725307] [PUBMED:21680046] [PUBMED:23351793] [PUBMED:21427764] [PUBMED:11676918] [PUBMED:22653444]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Centrosome maturation [NCBI:1269805] [REACTOME:R-HSA-380287] [PUBMED:17178454] [PUBMED:18437411]
Cilium Assembly [NCBI:1268846] [REACTOME:R-HSA-5617833] [PUBMED:21427764] [PUBMED:23351793] [PUBMED:25040720] [PUBMED:17955020] [PUBMED:22118932] [PUBMED:22653444] [PUBMED:22389062] [PUBMED:20399632] [PUBMED:25047619] [PUBMED:20395968] [PUBMED:23945166] [PUBMED:19575670] [PUBMED:24296415] [PUBMED:20145001] [PUBMED:19602418]
FoxO signaling pathway [NCBI:921162] [KEGG:hsa04068] [PUBMED:23325358] [PUBMED:15005655] [PUBMED:18951090] [PUBMED:22761423] [PUBMED:22902436] [PUBMED:16288288] [PUBMED:19701188] [PUBMED:16964248] [PUBMED:18045156] [PUBMED:18403263] [PUBMED:21613825] [PUBMED:21440011] [PUBMED:17470511] [PUBMED:21238503] [PUBMED:17522590] [PUBMED:15084259] [PUBMED:23801966] [PUBMED:17569704] [PUBMED:15516968]
G2/M Transition [NCBI:1269799] [REACTOME:R-HSA-69275]
Loss of Nlp from mitotic centrosomes [NCBI:1269809] [REACTOME:R-HSA-380259] [PUBMED:12852856]
Loss of proteins required for interphase microtubule organization from the centrosome [NCBI:1269808] [REACTOME:R-HSA-380284] [PUBMED:12140259] [PUBMED:12852856]
Mitotic G2-G2/M phases [NCBI:1269797] [REACTOME:R-HSA-453274]
Organelle biogenesis and maintenance [NCBI:1268838] [REACTOME:R-HSA-1852241] [PUBMED:8608592] [PUBMED:16103713]
PLK2 and PLK4 events [NCBI:138079] [Pathway Interaction Database:plk2_4pathway] [PUBMED:16244668] [PUBMED:16326102] [PUBMED:15242618]
Polo-like kinase signaling events in the cell cycle [NCBI:138077] [Pathway Interaction Database:plk_pathway]
Recruitment of mitotic centrosome proteins and complexes [NCBI:1269806] [REACTOME:R-HSA-380270] [PUBMED:18437411] [PUBMED:17178454]
Regulation of PLK1 Activity at G2/M Transition [NCBI:1269803] [REACTOME:R-HSA-2565942] [PUBMED:12207013] [PUBMED:18615013] [PUBMED:13678582] [PUBMED:18378770] [PUBMED:18566290] [PUBMED:18477460] [PUBMED:22365832]