full name
glutamate ionotropic receptor AMPA type subunit 2

synonyms
GluA2, GluR-K2, GLUR2, GLURB, HBGR2, GRIA2, ENSG00000120251

HGNC
HGNC:4572

Entrez Gene
Gene:2891

ENSEMBL
ENSG00000120251

location
chr: 4
start: 158141736
stop: 158287227
strand: +

OMIM
OMIM:138247: GRIA2
OMIM:618917: Neurodevelopmental disorder with language impairment and behavioral abnormalities

transcripts
ENST00000264426.9
ENST00000296526.7
ENST00000393815.2

pathways
Activation of AMPA receptors [NCBI:1268797] [REACTOME:R-HSA-399710] [PUBMED:7973663] [PUBMED:17256974] [PUBMED:16723221]
Activation of NMDA receptor upon glutamate binding and postsynaptic events [NCBI:1268798] [REACTOME:R-HSA-442755] [PUBMED:18616423]
Amphetamine addiction [NCBI:547607] [KEGG:hsa05031] [PUBMED:16776597] [PUBMED:18617632] [PUBMED:16724157] [PUBMED:19222557] [PUBMED:14746512] [PUBMED:18632938] [PUBMED:8630246] [PUBMED:14622123] [PUBMED:21338876] [PUBMED:8753884] [PUBMED:10774721] [PUBMED:14529709] [PUBMED:17728700] [PUBMED:21989194] [PUBMED:16151049] [PUBMED:18440072] [PUBMED:19199083] [PUBMED:10414964]
Amyotrophic lateral sclerosis (ALS) [NCBI:83099] [KEGG:hsa05014] [PUBMED:16026864] [PUBMED:16924260] [PUBMED:11513882] [PUBMED:17015226] [PUBMED:16723044] [PUBMED:10970056] [PUBMED:16909020] [PUBMED:12531867] [PUBMED:16713195] [PUBMED:16603792] [PUBMED:11870681] [PUBMED:16050975] [PUBMED:17409386] [PUBMED:11239414] [PUBMED:18519638] [PUBMED:14569202] [PUBMED:12728264] [PUBMED:11715057] [PUBMED:17566607] [PUBMED:17434459] [PUBMED:16909017] [PUBMED:12595144] [PUBMED:15310460] [PUBMED:14739060]
Circadian entrainment [NCBI:698773] [KEGG:hsa04713] [PUBMED:15016477] [PUBMED:12700026] [PUBMED:20605968] [PUBMED:15813931] [PUBMED:15930378] [PUBMED:12573527] [PUBMED:17586087] [PUBMED:20664079] [PUBMED:17646042] [PUBMED:17167088] [PUBMED:16217123] [PUBMED:11294753] [PUBMED:19109992] [PUBMED:10446325] [PUBMED:10208575] [PUBMED:11086993] [PUBMED:19449447]
Cocaine addiction [NCBI:546258] [KEGG:hsa05030] [PUBMED:15091342] [PUBMED:16278489] [PUBMED:14566342] [PUBMED:12064476] [PUBMED:16251986] [PUBMED:18440072] [PUBMED:19403004] [PUBMED:11595774] [PUBMED:11268215] [PUBMED:15582154] [PUBMED:12818179] [PUBMED:14746512] [PUBMED:10234039]
Dopaminergic synapse [NCBI:469199] [KEGG:hsa04728] [PUBMED:20727368] [PUBMED:10433257] [PUBMED:17408758] [PUBMED:15292232] [PUBMED:9457173] [PUBMED:17349698] [PUBMED:15521361] [PUBMED:18353279] [PUBMED:21303898] [PUBMED:19251795] [PUBMED:15381316] [PUBMED:15590733] [PUBMED:20224735] [PUBMED:19138563] [PUBMED:12967774]
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity [NCBI:1268794] [REACTOME:R-HSA-399721] [PUBMED:16904750] [PUBMED:16713244] [PUBMED:19217372]
Glutamatergic synapse [NCBI:213818] [KEGG:hsa04724] [PUBMED:10481192] [PUBMED:11561058] [PUBMED:18425072] [PUBMED:17706608] [PUBMED:20055706] [PUBMED:19112153] [PUBMED:17663464] [PUBMED:19110202] [PUBMED:19559598] [PUBMED:9665875] [PUBMED:11672421] [PUBMED:18464791] [PUBMED:12399578] [PUBMED:14684436]
Long-term depression [NCBI:83086] [KEGG:hsa04730] [PUBMED:9602501] [PUBMED:9735948] [PUBMED:14509570] [PUBMED:11427694] [PUBMED:12415297]
Long-term potentiation [NCBI:83085] [KEGG:hsa04720] [PUBMED:9697848] [PUBMED:15652868] [PUBMED:15803158] [PUBMED:11378299] [PUBMED:10652548] [PUBMED:15857686] [PUBMED:14715912]
N-cadherin signaling events [NCBI:137919] [Pathway Interaction Database:ncadherinpathway] [PUBMED:16319177] [PUBMED:19075000] [PUBMED:15121175] [PUBMED:15226396] [PUBMED:17765222] [PUBMED:7885471] [PUBMED:11086998] [PUBMED:2318342] [PUBMED:8050374] [PUBMED:9655503] [PUBMED:7962102] [PUBMED:7599959] [PUBMED:17459003] [PUBMED:9852580] [PUBMED:9052794] [PUBMED:17005551] [PUBMED:1837087] [PUBMED:1639850] [PUBMED:16176974] [PUBMED:16807326] [PUBMED:15716354] [PUBMED:8707857] [PUBMED:19162191] [PUBMED:12099895] [PUBMED:8113807] [PUBMED:16228908] [PUBMED:17538019] [PUBMED:11056534] [PUBMED:11809840] [PUBMED:11571292] [PUBMED:12377785] [PUBMED:8909549] [PUBMED:3780667] [PUBMED:9655504] [PUBMED:14610057] [PUBMED:15569714] [PUBMED:15662031] [PUBMED:15809310] [PUBMED:15247242] [PUBMED:2762814] [PUBMED:17289573] [PUBMED:17921113] [PUBMED:9712659] [PUBMED:12578907] [PUBMED:16515543] [PUBMED:15034585] [PUBMED:11106648] [PUBMED:11228159] [PUBMED:9786960] [PUBMED:12604612] [PUBMED:11466312] [PUBMED:11238727] [PUBMED:12640032] [PUBMED:1487503] [PUBMED:15383621] [PUBMED:8816706] [PUBMED:17481398] [PUBMED:9545083] [PUBMED:14657280] [PUBMED:12213839] [PUBMED:10930450]
Neuroactive ligand-receptor interaction [NCBI:83053] [KEGG:hsa04080]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell [NCBI:1268786] [REACTOME:R-HSA-112314]
Nicotine addiction [NCBI:583255] [KEGG:hsa05033] [PUBMED:19498417] [PUBMED:15661626] [PUBMED:12436424] [PUBMED:19669944] [PUBMED:19434058] [PUBMED:19184650] [PUBMED:15165747] [PUBMED:12716925] [PUBMED:18723034] [PUBMED:18640919] [PUBMED:11906697] [PUBMED:14708004] [PUBMED:17009926] [PUBMED:14747518] [PUBMED:20485364] [PUBMED:16251989] [PUBMED:20833261]
Retrograde endocannabinoid signaling [NCBI:537443] [KEGG:hsa04723] [PUBMED:16085309] [PUBMED:18515270] [PUBMED:15340387] [PUBMED:17636069] [PUBMED:17553427] [PUBMED:17404373] [PUBMED:19640475] [PUBMED:21117095] [PUBMED:18084639] [PUBMED:21187849] [PUBMED:18801434] [PUBMED:14978245] [PUBMED:21531987] [PUBMED:19553483] [PUBMED:19126760] [PUBMED:17419048] [PUBMED:18948642] [PUBMED:16968947]
Trafficking of AMPA receptors [NCBI:1268795] [REACTOME:R-HSA-399719] [PUBMED:19217372]
Trafficking of GluR2-containing AMPA receptors [NCBI:1268796] [REACTOME:R-HSA-416993] [PUBMED:18547676]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
Unblocking of NMDA receptor, glutamate binding and activation [NCBI:1268799] [REACTOME:R-HSA-438066] [PUBMED:9481670]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:10880354] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:24062645] [PUBMED:24450633] [PUBMED:21346730] [PUBMED:24613710] [PUBMED:21744067] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:18176800] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:24281338] [PUBMED:11117527] [PUBMED:16765984] [PUBMED:18323530] [PUBMED:18064650] [PUBMED:21852968] [PUBMED:11493633] [PUBMED:21212391] [PUBMED:15142747] [PUBMED:17077866] [PUBMED:19460777] [PUBMED:19874988] [PUBMED:16571352] [PUBMED:22022314]