full name
telomerase reverse transcriptase

synonyms
CMM9, DKCA2, DKCB4, EST2, hEST2, hTRT, PFBMFT1, TCS1, TP2, TRT, TERT, ENSG00000164362

HGNC
HGNC:11730

Entrez Gene
Gene:7015

ENSEMBL
ENSG00000164362

location
chr: 5
start: 1253282
stop: 1295178
strand: -

OMIM
OMIM:187270: TERT
OMIM:613989: {Dyskeratosis congenita, autosomal dominant 2}
OMIM:613989: {Dyskeratosis congenita, autosomal recessive 4}
OMIM:601626: {Leukemia, acute myeloid}
OMIM:615134: {Melanoma, cutaneous malignant, 9}
OMIM:614742: {Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1}

transcripts
NM_001193376.1
NM_198253.2

pathways
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Chromosome Maintenance [NCBI:1269853] [REACTOME:R-HSA-73886]
Extension of Telomeres [NCBI:1269857] [REACTOME:R-HSA-180786] [PUBMED:15189140]
Formation of the beta-catenin:TCF transactivating complex [NCBI:1269602] [REACTOME:R-HSA-201722] [PUBMED:19305417] [PUBMED:11713476] [PUBMED:18334222] [PUBMED:11934263] [PUBMED:16751178] [PUBMED:22617422] [PUBMED:20951344] [PUBMED:11136974] [PUBMED:19619488] [PUBMED:10831834] [PUBMED:21285352]
HIF-1-alpha transcription factor network [NCBI:138045] [Pathway Interaction Database:hif1_tfpathway] [PUBMED:11707426] [PUBMED:9242677] [PUBMED:9038135] [PUBMED:15310764] [PUBMED:11278891] [PUBMED:8816435] [PUBMED:8663540] [PUBMED:15235127] [PUBMED:12042299] [PUBMED:15312748] [PUBMED:14612449] [PUBMED:11342587] [PUBMED:12615703] [PUBMED:9632793] [PUBMED:12228247] [PUBMED:15044468] [PUBMED:8408001] [PUBMED:9822602] [PUBMED:15252039] [PUBMED:13679920] [PUBMED:11877282] [PUBMED:15235597] [PUBMED:15199161] [PUBMED:15104534] [PUBMED:10594042] [PUBMED:12354771] [PUBMED:10446188] [PUBMED:9436976] [PUBMED:11823643] [PUBMED:12370277] [PUBMED:8955077] [PUBMED:12879018] [PUBMED:14645546] [PUBMED:9486205] [PUBMED:9887100] [PUBMED:8089148] [PUBMED:15466858] [PUBMED:11708773] [PUBMED:15611046] [PUBMED:14742449] [PUBMED:15280364] [PUBMED:12215445] [PUBMED:15611089] [PUBMED:10777486] [PUBMED:9707622] [PUBMED:8917528] [PUBMED:15563275] [PUBMED:12067980] [PUBMED:10353251]
HTLV-I infection [NCBI:373901] [KEGG:hsa05166] [PUBMED:17446673] [PUBMED:16436385] [PUBMED:14686485] [PUBMED:19861996] [PUBMED:19092975] [PUBMED:11325603] [PUBMED:16155602] [PUBMED:12910251] [PUBMED:16155605] [PUBMED:16036567] [PUBMED:11244044] [PUBMED:18702816] [PUBMED:15569630] [PUBMED:21114861] [PUBMED:16155611] [PUBMED:17384582] [PUBMED:16155608] [PUBMED:10602469] [PUBMED:19014483] [PUBMED:9325311]
IL2 signaling events mediated by PI3K [NCBI:137938] [Pathway Interaction Database:il2_pi3kpathway] [PUBMED:15271800] [PUBMED:8617294] [PUBMED:7543780] [PUBMED:9092570] [PUBMED:9162082] [PUBMED:7737351] [PUBMED:9108028] [PUBMED:11486019] [PUBMED:1614535] [PUBMED:15843522] [PUBMED:7760801] [PUBMED:9029085] [PUBMED:1652056] [PUBMED:11994454] [PUBMED:12393431] [PUBMED:9771966] [PUBMED:10373522] [PUBMED:12525482] [PUBMED:3523754] [PUBMED:7736574] [PUBMED:10982827] [PUBMED:7589144] [PUBMED:7528328]
Regulation of Telomerase [NCBI:137987] [Pathway Interaction Database:telomerasepathway] [PUBMED:12037663] [PUBMED:11191110] [PUBMED:15381700] [PUBMED:10637317] [PUBMED:15314656] [PUBMED:10601322] [PUBMED:12545159] [PUBMED:11110707] [PUBMED:15371341] [PUBMED:12681489] [PUBMED:15824061] [PUBMED:15048073] [PUBMED:10850490] [PUBMED:16730176] [PUBMED:12181313] [PUBMED:16890531] [PUBMED:9837921] [PUBMED:10224060] [PUBMED:15331176] [PUBMED:16522649] [PUBMED:9822378] [PUBMED:15316005] [PUBMED:12699629] [PUBMED:16843438] [PUBMED:12151407] [PUBMED:12135483] [PUBMED:15655249] [PUBMED:10888888] [PUBMED:16765199] [PUBMED:16869756] [PUBMED:10837221] [PUBMED:16135795] [PUBMED:11074006] [PUBMED:11191109] [PUBMED:14712220] [PUBMED:16508638] [PUBMED:10471503] [PUBMED:11854288] [PUBMED:16785237] [PUBMED:9130722] [PUBMED:12956959] [PUBMED:15710386] [PUBMED:12586360] [PUBMED:12377759] [PUBMED:11433024] [PUBMED:15843522] [PUBMED:14749375] [PUBMED:11274138] [PUBMED:12676087] [PUBMED:16166375] [PUBMED:15371412]
Regulation of Wnt-mediated beta catenin signaling and target gene transcription [NCBI:169352] [Pathway Interaction Database:wnt_beta_catenin_pathway] [PUBMED:19901072] [PUBMED:19699733] [PUBMED:15142975] [PUBMED:16565090] [PUBMED:17372190] [PUBMED:17310985] [PUBMED:11751639] [PUBMED:16301527] [PUBMED:10921920] [PUBMED:8622675] [PUBMED:19571879] [PUBMED:11445543] [PUBMED:19066453] [PUBMED:15768032] [PUBMED:10704849] [PUBMED:19940019] [PUBMED:15378020] [PUBMED:10318916] [PUBMED:10617567] [PUBMED:19435523] [PUBMED:18511409] [PUBMED:18006687] [PUBMED:14638683] [PUBMED:15782138] [PUBMED:15143193] [PUBMED:9671490] [PUBMED:11263497] [PUBMED:18193033] [PUBMED:9751710] [PUBMED:11532957] [PUBMED:10898789] [PUBMED:11266540] [PUBMED:17090534] [PUBMED:15492215] [PUBMED:16309666] [PUBMED:12502739] [PUBMED:10980707] [PUBMED:17945188] [PUBMED:11572874] [PUBMED:11809808] [PUBMED:17113388] [PUBMED:20128690] [PUBMED:17709391] [PUBMED:11500377] [PUBMED:12464179] [PUBMED:18347071] [PUBMED:18347094] [PUBMED:15592430] [PUBMED:10958684] [PUBMED:12408825] [PUBMED:15525529] [PUBMED:16581771] [PUBMED:12052822] [PUBMED:15668231] [PUBMED:16014379] [PUBMED:17923689] [PUBMED:15592505] [PUBMED:10984057] [PUBMED:20044351] [PUBMED:11940574] [PUBMED:10747853] [PUBMED:12606575] [PUBMED:15728254] [PUBMED:11080158] [PUBMED:12446687] [PUBMED:20128911] [PUBMED:19816403] [PUBMED:18573912] [PUBMED:17397822] [PUBMED:10489374] [PUBMED:17052462] [PUBMED:20371816] [PUBMED:18347063] [PUBMED:11035805] [PUBMED:11792709] [PUBMED:16899215] [PUBMED:10882123] [PUBMED:12200448] [PUBMED:15060161] [PUBMED:12711682] [PUBMED:12582159] [PUBMED:12646922] [PUBMED:19460168] [PUBMED:16778892] [PUBMED:17306568] [PUBMED:12712206] [PUBMED:19711354] [PUBMED:17893322] [PUBMED:10934025] [PUBMED:19503085] [PUBMED:19433865]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
Telomere Extension By Telomerase [NCBI:1269858] [REACTOME:R-HSA-171319] [PUBMED:14685173] [PUBMED:15189140]
Telomere Maintenance [NCBI:1269856] [REACTOME:R-HSA-157579] [PUBMED:16166375] [PUBMED:4507727] [PUBMED:14685173] [PUBMED:642006] [PUBMED:15189140] [PUBMED:3907856] [PUBMED:2463488] [PUBMED:4754905]
Validated targets of C-MYC transcriptional activation [NCBI:169351] [Pathway Interaction Database:myc_activpathway] [PUBMED:18987359] [PUBMED:16537449] [PUBMED:9924025] [PUBMED:17643117] [PUBMED:8356088] [PUBMED:10688915] [PUBMED:1562593] [PUBMED:19020761] [PUBMED:10823814] [PUBMED:12637527] [PUBMED:9178906] [PUBMED:17967894] [PUBMED:15723053] [PUBMED:16508012] [PUBMED:8700224] [PUBMED:12091391] [PUBMED:20173740] [PUBMED:11522645] [PUBMED:15774466] [PUBMED:12776737] [PUBMED:12011429] [PUBMED:12138190] [PUBMED:10022128] [PUBMED:11511539] [PUBMED:12177005] [PUBMED:17599065] [PUBMED:6438521] [PUBMED:19745813] [PUBMED:8196628] [PUBMED:10891489] [PUBMED:8934531] [PUBMED:15723054] [PUBMED:9192621] [PUBMED:18042711] [PUBMED:10779353] [PUBMED:1989881] [PUBMED:8861962] [PUBMED:12529648] [PUBMED:16269333] [PUBMED:16172399] [PUBMED:8494784] [PUBMED:15282543] [PUBMED:8297793] [PUBMED:12776177] [PUBMED:9811896] [PUBMED:11103792] [PUBMED:17170079] [PUBMED:18593934] [PUBMED:11673469] [PUBMED:18408012] [PUBMED:1340466] [PUBMED:17088530] [PUBMED:8327497] [PUBMED:16423995] [PUBMED:12816956] [PUBMED:11598121] [PUBMED:14724288] [PUBMED:17848523] [PUBMED:10508165] [PUBMED:12695333] [PUBMED:17822678] [PUBMED:10606642] [PUBMED:9869632] [PUBMED:9212167] [PUBMED:19211792] [PUBMED:16287840] [PUBMED:18978814] [PUBMED:11511535] [PUBMED:15944709] [PUBMED:11604407] [PUBMED:11909865]