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Genes
PRKAA1
Gene - PRKAA1
full name
protein kinase AMP-activated catalytic subunit alpha 1
synonyms
AMPK, AMPKa1, PRKAA1, ENSG00000132356
HGNC
HGNC:9376
Entrez Gene
Gene:5562
ENSEMBL
ENSG00000132356
location
chr: 5
start: 40759481
stop: 40798297
strand: -
transcripts
NM_006251.5
NM_206907.3
pathways
AMPK signaling pathway
[NCBI:989139]
[KEGG:hsa04152]
[PUBMED:22885100]
[PUBMED:18725075]
[PUBMED:22700795]
[PUBMED:19724019]
[PUBMED:19584320]
[PUBMED:16644802]
[PUBMED:20010958]
[PUBMED:16479585]
[PUBMED:19197243]
[PUBMED:23565491]
[PUBMED:20357764]
[PUBMED:16723978]
[PUBMED:16054041]
[PUBMED:19393004]
[PUBMED:23899560]
[PUBMED:17307971]
[PUBMED:15509864]
[PUBMED:23024365]
[PUBMED:23747347]
[PUBMED:19629071]
Adipocytokine signaling pathway
[NCBI:83093]
[KEGG:hsa04920]
[PUBMED:12829246]
[PUBMED:10905472]
[PUBMED:15980064]
[PUBMED:12754525]
[PUBMED:12368907]
[PUBMED:11557972]
[PUBMED:15856064]
[PUBMED:9671776]
[PUBMED:10766253]
[PUBMED:15733744]
[PUBMED:15058305]
[PUBMED:14716305]
[PUBMED:11479627]
[PUBMED:14679176]
Apelin signaling pathway
[NCBI:1492886]
[KEGG:hsa04371]
[PUBMED:23973488]
[PUBMED:16182514]
[PUBMED:21725702]
[PUBMED:22842084]
[PUBMED:27825851]
[PUBMED:27650065]
[PUBMED:22140623]
[PUBMED:23943882]
[PUBMED:26944568]
[PUBMED:24055369]
[PUBMED:26385179]
[PUBMED:26143239]
[PUBMED:22028387]
[PUBMED:26254105]
[PUBMED:26756969]
[PUBMED:22995518]
[PUBMED:27979574]
[PUBMED:23924696]
[PUBMED:21464822]
[PUBMED:25914650]
[PUBMED:24990699]
[PUBMED:26607438]
[PUBMED:25164121]
[PUBMED:25275559]
[PUBMED:25139773]
[PUBMED:25931124]
[PUBMED:19093215]
[PUBMED:20539939]
[PUBMED:25652330]
[PUBMED:18272138]
[PUBMED:23603510]
Autophagy - animal
[NCBI:83058]
[KEGG:hsa04140]
[PUBMED:16200202]
[PUBMED:15325588]
[PUBMED:24343578]
[PUBMED:15978794]
[PUBMED:19802558]
[PUBMED:16099218]
[PUBMED:11099404]
[PUBMED:19653858]
[PUBMED:15325584]
[PUBMED:20034776]
[PUBMED:15928708]
[PUBMED:21801009]
[PUBMED:25948417]
[PUBMED:16125113]
[PUBMED:21187343]
Cellular responses to stress
[NCBI:1270414]
[REACTOME:R-HSA-2262752]
[PUBMED:15709958]
Circadian rhythm
[NCBI:83084]
[KEGG:hsa04710]
[PUBMED:17586087]
[PUBMED:12507418]
[PUBMED:10864977]
[PUBMED:18802415]
[PUBMED:17463251]
[PUBMED:12150932]
[PUBMED:11687489]
[PUBMED:12724733]
[PUBMED:12015613]
[PUBMED:11533719]
[PUBMED:12397359]
[PUBMED:15917222]
[PUBMED:11165242]
Energy dependent regulation of mTOR by LKB1-AMPK
[NCBI:1269439]
[REACTOME:R-HSA-380972]
[PUBMED:17613433]
[PUBMED:17712357]
[PUBMED:17010524]
Fluid shear stress and atherosclerosis
[NCBI:1474302]
[KEGG:hsa05418]
[PUBMED:23429585]
[PUBMED:21050140]
[PUBMED:17599600]
[PUBMED:24190880]
[PUBMED:22003002]
[PUBMED:24876354]
[PUBMED:24947523]
[PUBMED:23899566]
[PUBMED:26597822]
[PUBMED:20353494]
[PUBMED:22076424]
[PUBMED:20538799]
[PUBMED:25165867]
[PUBMED:20032497]
[PUBMED:23084990]
[PUBMED:26822720]
[PUBMED:24573382]
[PUBMED:23555159]
[PUBMED:26212910]
[PUBMED:21457103]
[PUBMED:19151844]
[PUBMED:15388638]
[PUBMED:16765337]
[PUBMED:27027326]
[PUBMED:25638487]
[PUBMED:21733876]
FoxO signaling pathway
[NCBI:921162]
[KEGG:hsa04068]
[PUBMED:23325358]
[PUBMED:15005655]
[PUBMED:18951090]
[PUBMED:22761423]
[PUBMED:22902436]
[PUBMED:16288288]
[PUBMED:19701188]
[PUBMED:16964248]
[PUBMED:18045156]
[PUBMED:18403263]
[PUBMED:21613825]
[PUBMED:21440011]
[PUBMED:17470511]
[PUBMED:21238503]
[PUBMED:17522590]
[PUBMED:15084259]
[PUBMED:23801966]
[PUBMED:17569704]
[PUBMED:15516968]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Glucagon signaling pathway
[NCBI:1144996]
[KEGG:hsa04922]
[PUBMED:20735177]
[PUBMED:19912989]
[PUBMED:21941300]
[PUBMED:22249520]
[PUBMED:12626323]
[PUBMED:16601267]
[PUBMED:18669612]
[PUBMED:24393785]
[PUBMED:21346730]
[PUBMED:22550228]
[PUBMED:16479585]
[PUBMED:24692138]
[PUBMED:22495310]
[PUBMED:22796337]
[PUBMED:22004992]
[PUBMED:24238363]
[PUBMED:22503562]
Hypertrophic cardiomyopathy (HCM)
[NCBI:114229]
[KEGG:hsa05410]
[PUBMED:11805847]
[PUBMED:18572189]
[PUBMED:14711353]
[PUBMED:19136482]
[PUBMED:18056765]
[PUBMED:11225594]
[PUBMED:12844200]
[PUBMED:10615904]
[PUBMED:11716909]
[PUBMED:11371514]
[PUBMED:12270949]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Insulin resistance
[NCBI:1272486]
[KEGG:hsa04931]
[PUBMED:17130651]
[PUBMED:20466550]
[PUBMED:16364488]
[PUBMED:12765939]
[PUBMED:15166380]
[PUBMED:7666792]
[PUBMED:16756496]
[PUBMED:23647930]
[PUBMED:10923637]
[PUBMED:17141630]
[PUBMED:9886945]
[PUBMED:8048519]
[PUBMED:18309108]
[PUBMED:15107844]
[PUBMED:20526383]
[PUBMED:22360800]
[PUBMED:16186396]
[PUBMED:22675355]
[PUBMED:22677645]
Insulin signaling pathway
[NCBI:83090]
[KEGG:hsa04910]
[PUBMED:11742412]
[PUBMED:11343120]
[PUBMED:15733744]
[PUBMED:11282018]
[PUBMED:10196204]
[PUBMED:18291668]
[PUBMED:9609110]
[PUBMED:10567225]
[PUBMED:12791379]
[PUBMED:9748166]
[PUBMED:15624019]
[PUBMED:9445476]
[PUBMED:9346240]
[PUBMED:14635525]
[PUBMED:16288289]
[PUBMED:12867054]
[PUBMED:15229476]
[PUBMED:17344645]
[PUBMED:9609111]
Longevity regulating pathway
[NCBI:1319989]
[KEGG:hsa04211]
[PUBMED:21779512]
[PUBMED:23594965]
[PUBMED:25654554]
[PUBMED:25832544]
[PUBMED:24997879]
[PUBMED:22618766]
[PUBMED:20336132]
[PUBMED:24905167]
[PUBMED:25601466]
[PUBMED:20103737]
[PUBMED:18692468]
[PUBMED:20395504]
[PUBMED:25824609]
[PUBMED:17701476]
[PUBMED:23939249]
[PUBMED:20848587]
[PUBMED:22983298]
[PUBMED:19262508]
[PUBMED:20357764]
[PUBMED:18946478]
[PUBMED:23061800]
Longevity regulating pathway - multiple species
[NCBI:1340713]
[KEGG:hsa04213]
[PUBMED:26682004]
[PUBMED:20098959]
[PUBMED:17684529]
[PUBMED:14534077]
[PUBMED:16304601]
[PUBMED:17701476]
[PUBMED:20395504]
[PUBMED:18373439]
[PUBMED:20336132]
[PUBMED:21909281]
[PUBMED:26525455]
[PUBMED:22094419]
[PUBMED:12610293]
[PUBMED:15768047]
[PUBMED:23615258]
[PUBMED:18946478]
[PUBMED:20097433]
[PUBMED:21841070]
[PUBMED:25153840]
Macroautophagy
[NCBI:1270432]
[REACTOME:R-HSA-1632852]
[PUBMED:24296784]
Non-alcoholic fatty liver disease (NAFLD)
[NCBI:862188]
[KEGG:hsa04932]
[PUBMED:21038418]
[PUBMED:17498512]
[PUBMED:19352614]
[PUBMED:23299992]
[PUBMED:22570745]
[PUBMED:9285483]
[PUBMED:12891546]
[PUBMED:18061659]
[PUBMED:22705006]
[PUBMED:16364488]
[PUBMED:18242193]
[PUBMED:16374858]
[PUBMED:22940046]
[PUBMED:20619513]
[PUBMED:20303879]
[PUBMED:14685853]
[PUBMED:16406828]
[PUBMED:23545492]
[PUBMED:21145844]
Oxytocin signaling pathway
[NCBI:952859]
[KEGG:hsa04921]
[PUBMED:23356278]
[PUBMED:9219843]
[PUBMED:20626426]
[PUBMED:18555543]
[PUBMED:22190926]
[PUBMED:21981277]
[PUBMED:9575824]
[PUBMED:22227279]
[PUBMED:19840865]
[PUBMED:11861513]
[PUBMED:9326674]
[PUBMED:12433531]
[PUBMED:18655881]
[PUBMED:23335873]
[PUBMED:22902539]
[PUBMED:16156781]
[PUBMED:20141572]
[PUBMED:14715914]
[PUBMED:12009385]
[PUBMED:16787565]
[PUBMED:16966388]
PI3K Cascade
[NCBI:1269432]
[REACTOME:R-HSA-109704]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
PKB-mediated events
[NCBI:1269434]
[REACTOME:R-HSA-109703]
Regulation of TP53 Activity
[NCBI:1383076]
[REACTOME:R-HSA-5633007]
[PUBMED:19450511]
[PUBMED:20457558]
[PUBMED:23825024]
[PUBMED:25641576]
Regulation of TP53 Activity through Phosphorylation
[NCBI:1383080]
[REACTOME:R-HSA-6804756]
[PUBMED:11780126]
[PUBMED:21317932]
[PUBMED:15866171]
[PUBMED:12393879]
[PUBMED:11740489]
[PUBMED:11447225]
[PUBMED:9733515]
[PUBMED:12851404]
[PUBMED:10884347]
[PUBMED:10710310]
[PUBMED:11239457]
[PUBMED:9925639]
[PUBMED:11546806]
[PUBMED:11551930]
[PUBMED:10570149]
[PUBMED:18490454]
[PUBMED:17591690]
[PUBMED:19965871]
[PUBMED:12064478]
[PUBMED:10673501]
[PUBMED:22611192]
[PUBMED:9843217]
[PUBMED:15053879]
[PUBMED:12914926]
[PUBMED:10673500]
[PUBMED:17349958]
[PUBMED:14702041]
[PUBMED:20959462]
[PUBMED:10435622]
[PUBMED:9733514]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
TP53 Regulates Metabolic Genes
[NCBI:1269655]
[REACTOME:R-HSA-5628897]
[PUBMED:19822145]
[PUBMED:12453409]
[PUBMED:18344994]
[PUBMED:11545734]
[PUBMED:16839880]
[PUBMED:20399660]
[PUBMED:15105503]
[PUBMED:13298683]
[PUBMED:15665293]
[PUBMED:18198340]
[PUBMED:18692468]
[PUBMED:12203114]
[PUBMED:17409411]
[PUBMED:11959846]
[PUBMED:16728594]
[PUBMED:17486094]
[PUBMED:23484829]
[PUBMED:22682249]
[PUBMED:19696408]
[PUBMED:9926927]
[PUBMED:22864287]
[PUBMED:20378837]
[PUBMED:18391940]
[PUBMED:24366874]
[PUBMED:19439913]
[PUBMED:15059920]
[PUBMED:10716435]
[PUBMED:17540029]
Tight junction
[NCBI:83071]
[KEGG:hsa04530]
[PUBMED:25152334]
[PUBMED:16650994]
[PUBMED:22892070]
[PUBMED:18946474]
[PUBMED:12042308]
[PUBMED:23885123]
[PUBMED:16771626]
[PUBMED:17182900]
[PUBMED:21283798]
[PUBMED:25757376]
[PUBMED:22928510]
[PUBMED:22169974]
[PUBMED:25469537]
[PUBMED:24651541]
[PUBMED:15820555]
[PUBMED:17525755]
[PUBMED:27353478]
[PUBMED:17950242]
[PUBMED:18005931]
[PUBMED:24548561]
[PUBMED:21781017]
[PUBMED:20094051]
[PUBMED:20134025]
[PUBMED:22896795]
[PUBMED:18094055]
[PUBMED:25483301]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
mTOR signaling pathway
[NCBI:83059]
[KEGG:hsa04150]
[NCBI:138001]
[Pathway Interaction Database:mtor_4pathway]
[PUBMED:17277771]
[PUBMED:15341740]
[PUBMED:12172553]
[PUBMED:15718470]
[PUBMED:14651849]
[PUBMED:15268862]
[PUBMED:15306821]
[PUBMED:26046644]
[PUBMED:12869586]
[PUBMED:24556838]
[PUBMED:17928295]
[PUBMED:9427642]
[PUBMED:18046414]
[PUBMED:12912918]
[PUBMED:16286006]
[PUBMED:26658722]
[PUBMED:24842496]
[PUBMED:23465396]
[PUBMED:17709744]
[PUBMED:17599906]
[PUBMED:16919458]
[PUBMED:10364159]
[PUBMED:15342917]
[PUBMED:11500364]
[PUBMED:19812304]
[PUBMED:12482958]
[PUBMED:11729323]
[PUBMED:16962653]
[PUBMED:18952604]
[PUBMED:9465032]
[PUBMED:1496022]
[PUBMED:10567431]
[PUBMED:19114562]
[PUBMED:17510057]
[PUBMED:18604198]
[PUBMED:15545625]
[PUBMED:11914378]
[PUBMED:17461779]
[PUBMED:9445476]
[PUBMED:18497260]
[PUBMED:12604610]
[PUBMED:15071500]
[PUBMED:18925875]
[PUBMED:12906785]
[PUBMED:11287630]
[PUBMED:15004009]
[PUBMED:16756488]
[PUBMED:17043309]
[PUBMED:18198340]
[PUBMED:12820960]
[PUBMED:12747827]
[PUBMED:17053147]
[PUBMED:15851026]
[PUBMED:15467718]
[PUBMED:18762023]
[PUBMED:25242279]
[PUBMED:24698685]
[PUBMED:11175345]
[PUBMED:27304501]
[PUBMED:18411301]
[PUBMED:11500365]
[PUBMED:17693255]
[PUBMED:23694989]
[PUBMED:12231510]
[PUBMED:19446321]
[PUBMED:11418588]
[PUBMED:19258318]
[PUBMED:18439900]
[PUBMED:19225151]
[PUBMED:26185979]
[PUBMED:10357815]
[PUBMED:26269525]
[PUBMED:23421405]
[PUBMED:9271440]
[PUBMED:16915281]
[PUBMED:17141160]
[PUBMED:15249583]
[PUBMED:12912989]
[PUBMED:27027448]
[PUBMED:18423201]
[PUBMED:19211835]
[PUBMED:9204908]
[PUBMED:26700098]
[PUBMED:18566587]
[PUBMED:17386266]
mTOR signalling
[NCBI:1269436]
[REACTOME:R-HSA-165159]
[PUBMED:21157483]