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Genes
F2R
Gene - F2R
full name
coagulation factor II thrombin receptor
synonyms
CF2R, HTR, PAR-1, PAR1, TR, F2R, ENSG00000181104
HGNC
HGNC:3537
Entrez Gene
Gene:2149
ENSEMBL
ENSG00000181104
location
chr: 5
start: 76011868
stop: 76031595
strand: +
transcripts
NM_001992.3
pathways
Calcium signaling pathway
[NCBI:83050]
[KEGG:hsa04020]
[PUBMED:11080247]
[PUBMED:14572802]
[PUBMED:11413485]
[PUBMED:22129055]
[PUBMED:10508738]
[PUBMED:15000521]
[PUBMED:9235901]
[PUBMED:7861177]
[PUBMED:9149541]
[PUBMED:14517314]
[PUBMED:15111104]
[PUBMED:11698232]
[PUBMED:10331643]
[PUBMED:12838335]
[PUBMED:8125957]
[PUBMED:19172794]
[PUBMED:10997573]
[PUBMED:21338471]
[PUBMED:11299192]
[PUBMED:22002090]
[PUBMED:12972622]
Class A/1 (Rhodopsin-like receptors)
[NCBI:1269545]
[REACTOME:R-HSA-373076]
[PUBMED:16902930]
Common Pathway of Fibrin Clot Formation
[NCBI:1269371]
[REACTOME:R-HSA-140875]
[PUBMED:1931959]
Complement and coagulation cascades
[NCBI:83073]
[KEGG:hsa04610]
[PUBMED:23564577]
[PUBMED:25309880]
[PUBMED:26082779]
[PUBMED:23110467]
[PUBMED:20027185]
[PUBMED:25568220]
[PUBMED:26324800]
[PUBMED:25705421]
[PUBMED:21811895]
[PUBMED:23911436]
[PUBMED:23564578]
[PUBMED:24924409]
[PUBMED:26489954]
[PUBMED:17635716]
Endocytosis
[NCBI:102279]
[KEGG:hsa04144]
[PUBMED:19696797]
[PUBMED:19007773]
[PUBMED:16203612]
[PUBMED:15687999]
[PUBMED:19924646]
[PUBMED:15261671]
[PUBMED:18647649]
[PUBMED:19325624]
[PUBMED:20110990]
[PUBMED:22193161]
Formation of Fibrin Clot (Clotting Cascade)
[NCBI:1269368]
[REACTOME:R-HSA-140877]
[PUBMED:1931959]
[PUBMED:12524220]
G alpha (q) signalling events
[NCBI:1269578]
[REACTOME:R-HSA-416476]
[PUBMED:19212139]
GPCR downstream signaling
[NCBI:1269574]
[REACTOME:R-HSA-388396]
[PUBMED:12040175]
GPCR ligand binding
[NCBI:1269544]
[REACTOME:R-HSA-500792]
[PUBMED:15251227]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
Hemostasis
[NCBI:1269340]
[REACTOME:R-HSA-109582]
Neuroactive ligand-receptor interaction
[NCBI:83053]
[KEGG:hsa04080]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Peptide ligand-binding receptors
[NCBI:1269546]
[REACTOME:R-HSA-375276]
[PUBMED:14576899]
[PUBMED:10977869]
[PUBMED:16918325]
[PUBMED:16847439]
[PUBMED:17293890]
[PUBMED:15734727]
[PUBMED:12895595]
[PUBMED:17604107]
[PUBMED:14507421]
[PUBMED:12432945]
[PUBMED:16612131]
Phospholipase D signaling pathway
[NCBI:1311074]
[KEGG:hsa04072]
[PUBMED:9310372]
[PUBMED:9119890]
[PUBMED:15310762]
[PUBMED:18936782]
[PUBMED:24990952]
[PUBMED:14769825]
[PUBMED:21936578]
[PUBMED:10666319]
[PUBMED:17210675]
[PUBMED:19264150]
[PUBMED:23076158]
[PUBMED:17054901]
[PUBMED:16622417]
[PUBMED:10807766]
[PUBMED:12217395]
[PUBMED:11042115]
[PUBMED:19815110]
[PUBMED:24995811]
[PUBMED:16143829]
[PUBMED:8135758]
[PUBMED:11991733]
[PUBMED:19410013]
[PUBMED:17245604]
Platelet activation
[NCBI:952858]
[KEGG:hsa04611]
[PUBMED:20002545]
[PUBMED:18363565]
[PUBMED:18544684]
[PUBMED:18174460]
[PUBMED:23106920]
[PUBMED:18550847]
[PUBMED:22119499]
[PUBMED:19630797]
[PUBMED:19286885]
[PUBMED:17158345]
[PUBMED:20089227]
[PUBMED:22701130]
[PUBMED:21071698]
[PUBMED:23805129]
[PUBMED:16149014]
[PUBMED:18641368]
Platelet activation, signaling and aggregation
[NCBI:1269350]
[REACTOME:R-HSA-76002]
[PUBMED:16543958]
[PUBMED:8704248]
[PUBMED:2018971]
[PUBMED:1672265]
[PUBMED:17059469]
[PUBMED:12681240]
[PUBMED:12411949]
[PUBMED:11511514]
Rap1 signaling pathway
[NCBI:868086]
[KEGG:hsa04015]
[PUBMED:17624944]
[PUBMED:12351703]
[PUBMED:10579920]
[PUBMED:19159611]
[PUBMED:18363565]
[PUBMED:12765839]
[PUBMED:12508104]
[PUBMED:11331911]
[PUBMED:17182900]
[PUBMED:15803158]
[PUBMED:19615876]
[PUBMED:21402149]
[PUBMED:17624948]
[PUBMED:17383543]
[PUBMED:14607972]
[PUBMED:15780587]
[PUBMED:19710505]
Regulation of actin cytoskeleton
[NCBI:83089]
[KEGG:hsa04810]
[PUBMED:11152757]
[PUBMED:11082272]
[PUBMED:10574699]
[PUBMED:11082269]
[PUBMED:14657486]
[PUBMED:14744429]
[PUBMED:12700767]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Thrombin signalling through proteinase activated receptors (PARs)
[NCBI:1269356]
[REACTOME:R-HSA-456926]
[PUBMED:11001069]
cAMP signaling pathway
[NCBI:1017634]
[KEGG:hsa04024]
[PUBMED:10880354]
[PUBMED:9204709]
[PUBMED:21693691]
[PUBMED:24062645]
[PUBMED:24450633]
[PUBMED:21346730]
[PUBMED:24613710]
[PUBMED:21744067]
[PUBMED:22082266]
[PUBMED:16460276]
[PUBMED:18176800]
[PUBMED:14715909]
[PUBMED:7688165]
[PUBMED:24281338]
[PUBMED:11117527]
[PUBMED:16765984]
[PUBMED:18323530]
[PUBMED:18064650]
[PUBMED:21852968]
[PUBMED:11493633]
[PUBMED:21212391]
[PUBMED:15142747]
[PUBMED:17077866]
[PUBMED:19460777]
[PUBMED:19874988]
[PUBMED:16571352]
[PUBMED:22022314]