full name
dihydrofolate reductase

synonyms
DHFRP1, DYR, DHFR, ENSG00000228716

HGNC
HGNC:2861

Entrez Gene
Gene:1719

ENSEMBL
ENSG00000228716

location
chr: 5
start: 79922045
stop: 79950800
strand: -

OMIM
OMIM:126060: DHFR (Autosomal recessive inheritance)
OMIM:613839: Megaloblastic anemia due to dihydrofolate reductase deficiency

transcripts
NM_000791.3

pathways
Antifolate resistance [NCBI:1440526] [KEGG:hsa01523] [PUBMED:17333344] [PUBMED:23987246] [PUBMED:11509639] [PUBMED:24732946] [PUBMED:8793930] [PUBMED:15117425] [PUBMED:22921318] [PUBMED:16491071] [PUBMED:26920997] [PUBMED:22954694] [PUBMED:17092765] [PUBMED:17203006] [PUBMED:23897011] [PUBMED:21317831] [PUBMED:18297517] [PUBMED:14576850] [PUBMED:16380836]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
E2F mediated regulation of DNA replication [NCBI:1269774] [REACTOME:R-HSA-113510] [PUBMED:12393009] [PUBMED:12726857] [PUBMED:12473340]
E2F transcription factor network [NCBI:137934] [Pathway Interaction Database:e2f_pathway] [PUBMED:15175242] [PUBMED:11034215] [PUBMED:8832394] [PUBMED:7479977] [PUBMED:12077144] [PUBMED:11274364] [PUBMED:8618861] [PUBMED:11857079] [PUBMED:7958837] [PUBMED:15014447] [PUBMED:9774682] [PUBMED:9704927] [PUBMED:9271400] [PUBMED:8334989] [PUBMED:16288221] [PUBMED:10766737] [PUBMED:8657141] [PUBMED:8552092] [PUBMED:11101847] [PUBMED:12757710] [PUBMED:17704056] [PUBMED:7705662] [PUBMED:15897886] [PUBMED:9192872] [PUBMED:9778043] [PUBMED:12766778] [PUBMED:15510213] [PUBMED:11418595] [PUBMED:10454584] [PUBMED:10783242] [PUBMED:11904439] [PUBMED:16179649] [PUBMED:7791762] [PUBMED:11719808] [PUBMED:12389032] [PUBMED:8264596] [PUBMED:19491197] [PUBMED:15713665] [PUBMED:16357170] [PUBMED:9689056] [PUBMED:12748276] [PUBMED:2524830] [PUBMED:14633988] [PUBMED:12697828] [PUBMED:12101096] [PUBMED:11799067] [PUBMED:15133492] [PUBMED:16892051] [PUBMED:8943353] [PUBMED:9724731] [PUBMED:10030670] [PUBMED:11459832] [PUBMED:8114719] [PUBMED:9520412] [PUBMED:18348985] [PUBMED:9020173] [PUBMED:11389439] [PUBMED:16211008] [PUBMED:12411495] [PUBMED:7958836] [PUBMED:12909625] [PUBMED:15306814] [PUBMED:10688648] [PUBMED:12611887] [PUBMED:9191053] [PUBMED:10373518] [PUBMED:10187822]
Folate biosynthesis [NCBI:83018] [KEGG:hsa00790] [PUBMED:16632608] [PUBMED:19675644] [PUBMED:12571226] [PUBMED:18092812]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G1/S-Specific Transcription [NCBI:1269772] [REACTOME:R-HSA-69205]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of folate and pterines [NCBI:1270156] [REACTOME:R-HSA-196757] [PUBMED:10466189] [PUBMED:11001804]
Metabolism of nitric oxide [NCBI:1270115] [REACTOME:R-HSA-202131] [PUBMED:17237348]
Metabolism of vitamins and cofactors [NCBI:1270144] [REACTOME:R-HSA-196854]
Metabolism of water-soluble vitamins and cofactors [NCBI:1270145] [REACTOME:R-HSA-196849]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
One carbon pool by folate [NCBI:83008] [KEGG:hsa00670]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation [NCBI:1270120] [REACTOME:R-HSA-1474151] [PUBMED:17555404] [PUBMED:21550412] [PUBMED:10727395] [PUBMED:18321209]
eNOS activation and regulation [NCBI:1270116] [REACTOME:R-HSA-203765] [PUBMED:12842859] [PUBMED:16722822]