full name
RAS p21 protein activator 1
synonyms
CM-AVM, CMAVM, GAP, p120GAP, p120RASGAP, PKWS, RASA, RASGAP, RASA1, ENSG00000145715
HGNC
HGNC:9871
Entrez Gene
Gene:5921
ENSEMBL
ENSG00000145715
location
chr: 5
start: 86564070
stop: 86687743
strand: +
OMIM
OMIM:139150:
RASA1
OMIM:605462:
Basal cell carcinoma, somatic
OMIM:608354:
Capillary malformation-arteriovenous malformation 1
transcripts
NM_002890.2
NM_022650.2
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Angiopoietin receptor Tie2-mediated signaling
[NCBI:137917]
[Pathway Interaction Database:angiopoietinreceptor_pathway]
[PUBMED:9204896]
[PUBMED:12609966]
[PUBMED:14726409]
[PUBMED:11157678]
[PUBMED:10347092]
[PUBMED:11967990]
[PUBMED:15162796]
[PUBMED:11289054]
[PUBMED:12759249]
[PUBMED:10051567]
[PUBMED:12824293]
[PUBMED:16895971]
[PUBMED:10807867]
[PUBMED:12933576]
[PUBMED:11513602]
[PUBMED:12074640]
[PUBMED:8980223]
[PUBMED:14665640]
[PUBMED:15132996]
[PUBMED:10944458]
[PUBMED:11230987]
[PUBMED:15242771]
[PUBMED:10585289]
[PUBMED:16061664]
[PUBMED:10376602]
[PUBMED:15350545]
[PUBMED:9632797]
[PUBMED:10625301]
[PUBMED:9926914]
[PUBMED:17189382]
[PUBMED:11139469]
[PUBMED:11689432]
[PUBMED:11416142]
[PUBMED:11166279]
[PUBMED:15284220]
[PUBMED:15985432]
[PUBMED:16049136]
[PUBMED:16157706]
[PUBMED:10521483]
[PUBMED:12816861]
[PUBMED:9478921]
[PUBMED:10376603]
[PUBMED:15769741]
[PUBMED:12890486]
[PUBMED:14749497]
[PUBMED:7561682]
[PUBMED:11801735]
[PUBMED:12665569]
[PUBMED:12117724]
[PUBMED:9764820]
Aurora A signaling
[NCBI:137925]
[Pathway Interaction Database:aurora_a_pathway]
[PUBMED:17308110]
[PUBMED:16894566]
[PUBMED:16631581]
[PUBMED:17229885]
[PUBMED:15128871]
[PUBMED:14990569]
[PUBMED:12177045]
[PUBMED:14580337]
[PUBMED:14724178]
[PUBMED:17545617]
[PUBMED:15687499]
[PUBMED:11163242]
[PUBMED:14603251]
[PUBMED:17060449]
[PUBMED:12208850]
[PUBMED:12815066]
[PUBMED:17125467]
[PUBMED:13678582]
[PUBMED:15987997]
[PUBMED:15966895]
[PUBMED:11976319]
[PUBMED:14702041]
[PUBMED:16246726]
[PUBMED:17452972]
[PUBMED:12082625]
[PUBMED:11039908]
[PUBMED:14667408]
[PUBMED:12577065]
[PUBMED:14600264]
[PUBMED:11756469]
[PUBMED:16772293]
[PUBMED:12023018]
[PUBMED:15469940]
[PUBMED:16082213]
Aurora B signaling
[NCBI:138080]
[Pathway Interaction Database:aurora_b_pathway]
[PUBMED:14960279]
[PUBMED:15249581]
[PUBMED:17129783]
[PUBMED:15263015]
[PUBMED:15854913]
[PUBMED:14605209]
[PUBMED:12689593]
[PUBMED:15499654]
[PUBMED:17483322]
[PUBMED:15316025]
[PUBMED:11350965]
[PUBMED:11516652]
[PUBMED:11976319]
[PUBMED:16222246]
[PUBMED:12925766]
[PUBMED:15260989]
[PUBMED:16764853]
[PUBMED:15796717]
[PUBMED:16916643]
[PUBMED:14667408]
[PUBMED:17389228]
[PUBMED:16687578]
[PUBMED:14722118]
[PUBMED:12082625]
[PUBMED:17356064]
[PUBMED:16222244]
[PUBMED:11756469]
[PUBMED:17457057]
[PUBMED:15350530]
[PUBMED:17322402]
[PUBMED:11856369]
[PUBMED:17199039]
[PUBMED:17129782]
[PUBMED:12419797]
[PUBMED:16046481]
[PUBMED:15064709]
[PUBMED:12458200]
[PUBMED:15064354]
[PUBMED:14674694]
[PUBMED:16179162]
[PUBMED:17543862]
[PUBMED:17215513]
[PUBMED:12686604]
[PUBMED:16537398]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
BCR signaling pathway
[NCBI:138058]
[Pathway Interaction Database:bcr_5pathway]
[PUBMED:7687428]
[PUBMED:16200195]
[PUBMED:12730099]
[PUBMED:10770799]
[PUBMED:14563325]
[PUBMED:9763608]
[PUBMED:15541657]
[PUBMED:11781242]
[PUBMED:11102801]
[PUBMED:9586640]
[PUBMED:11279148]
[PUBMED:7499277]
[PUBMED:7542197]
[PUBMED:9820480]
[PUBMED:9221755]
[PUBMED:11909947]
[PUBMED:9360945]
[PUBMED:9058799]
[PUBMED:10339589]
[PUBMED:11226282]
[PUBMED:9271416]
[PUBMED:9620684]
[PUBMED:11163197]
[PUBMED:10820378]
[PUBMED:11356195]
[PUBMED:11080163]
[PUBMED:10755621]
[PUBMED:7717978]
[PUBMED:7618087]
[PUBMED:11577348]
[PUBMED:1279802]
[PUBMED:10640270]
[PUBMED:11356834]
[PUBMED:12867038]
[PUBMED:12780340]
[PUBMED:10430908]
[PUBMED:7528218]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases of signal transduction
[NCBI:1268855]
[REACTOME:R-HSA-5663202]
[PUBMED:12509752]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
EGF receptor (ErbB1) signaling pathway
[NCBI:137970]
[Pathway Interaction Database:erbb1_receptor_proximal_pathway]
[PUBMED:15284024]
[PUBMED:15574420]
[PUBMED:12024020]
[PUBMED:10913131]
[PUBMED:2176151]
[PUBMED:8479540]
[PUBMED:8386805]
[PUBMED:10648629]
[PUBMED:7478566]
[PUBMED:9307968]
[PUBMED:6090944]
[PUBMED:1850098]
[PUBMED:7970708]
[PUBMED:12522133]
[PUBMED:1537335]
[PUBMED:10075741]
[PUBMED:9454735]
[PUBMED:9049300]
[PUBMED:9642214]
[PUBMED:14560030]
[PUBMED:9079708]
[PUBMED:12952932]
[PUBMED:10806474]
[PUBMED:1689011]
[PUBMED:7681824]
[PUBMED:9038217]
[PUBMED:7525285]
[PUBMED:14963038]
[PUBMED:7592690]
[PUBMED:1860884]
[PUBMED:19401591]
[PUBMED:12464621]
[PUBMED:8596638]
[PUBMED:7478553]
[PUBMED:8626525]
[PUBMED:8479541]
[PUBMED:7962064]
[PUBMED:10675331]
[PUBMED:8106552]
[PUBMED:9989831]
[PUBMED:10816576]
[PUBMED:7527043]
[PUBMED:2171993]
[PUBMED:12424235]
[PUBMED:7923364]
[PUBMED:2173144]
[PUBMED:7993895]
[PUBMED:8034616]
[PUBMED:9733788]
[PUBMED:2153914]
[PUBMED:1322798]
[PUBMED:14498832]
[PUBMED:8621459]
[PUBMED:7898933]
[PUBMED:9121432]
[PUBMED:11950594]
[PUBMED:7673163]
[PUBMED:7689150]
[PUBMED:1623525]
[PUBMED:8824201]
[PUBMED:8798379]
[PUBMED:8707848]
[PUBMED:15550174]
[PUBMED:8940013]
[PUBMED:10669730]
[PUBMED:8479536]
[PUBMED:17635937]
[PUBMED:18269246]
[PUBMED:10411909]
[PUBMED:7542246]
[PUBMED:7488034]
[PUBMED:2005883]
[PUBMED:1689310]
[PUBMED:7823926]
[PUBMED:16055672]
[PUBMED:2236073]
[PUBMED:8490966]
[PUBMED:18156174]
[PUBMED:8628261]
[PUBMED:8816994]
[PUBMED:8895577]
[PUBMED:11134009]
[PUBMED:9355745]
[PUBMED:1315766]
[PUBMED:1700866]
[PUBMED:9346957]
[PUBMED:7518560]
EPH-Ephrin signaling
[NCBI:1270330]
[REACTOME:R-HSA-2682334]
[PUBMED:18281458]
[PUBMED:22120527]
EPHB forward signaling
[NCBI:138047]
[Pathway Interaction Database:ephbfwdpathway]
[PUBMED:8808709]
[PUBMED:11780069]
[PUBMED:11585923]
[PUBMED:10644995]
[PUBMED:12223469]
[PUBMED:15351694]
[PUBMED:12973357]
[PUBMED:15107421]
[PUBMED:9233798]
[PUBMED:7973638]
[PUBMED:12389031]
[PUBMED:15536074]
[PUBMED:8755474]
[PUBMED:9430661]
[PUBMED:12546821]
[PUBMED:15107857]
[PUBMED:14500293]
[PUBMED:12925710]
[PUBMED:8878483]
[PUBMED:8918835]
[PUBMED:10669731]
[PUBMED:10570155]
[PUBMED:8761303]
[PUBMED:12408869]
[PUBMED:15821731]
[PUBMED:12475948]
EPHB-mediated forward signaling
[NCBI:1270332]
[REACTOME:R-HSA-3928662]
[PUBMED:12808016]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Fc-epsilon receptor I signaling in mast cells
[NCBI:138050]
[Pathway Interaction Database:fcer1pathway]
[PUBMED:9556577]
[PUBMED:8629002]
[PUBMED:12217401]
[PUBMED:15010370]
[PUBMED:15608142]
[PUBMED:7561053]
[PUBMED:7537741]
[PUBMED:7963537]
[PUBMED:8947047]
[PUBMED:1384468]
[PUBMED:14757742]
[PUBMED:16174756]
[PUBMED:10583594]
[PUBMED:7513150]
[PUBMED:12089510]
[PUBMED:10811803]
[PUBMED:9268346]
[PUBMED:12640123]
[PUBMED:9108083]
[PUBMED:8602265]
[PUBMED:11340169]
[PUBMED:12953098]
[PUBMED:11465115]
[PUBMED:7730640]
[PUBMED:9550384]
[PUBMED:7518558]
[PUBMED:11137136]
[PUBMED:15282299]
[PUBMED:14634134]
[PUBMED:8534912]
[PUBMED:16002993]
[PUBMED:12192036]
[PUBMED:7608202]
[PUBMED:11714805]
[PUBMED:11970986]
[PUBMED:10903718]
[PUBMED:15265912]
[PUBMED:15477350]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IL2-mediated signaling events
[NCBI:137976]
[Pathway Interaction Database:il2_1pathway]
[PUBMED:7568005]
[PUBMED:10962026]
[PUBMED:1545122]
[PUBMED:10602027]
[PUBMED:15170389]
[PUBMED:9092570]
[PUBMED:7509794]
[PUBMED:15356145]
[PUBMED:9973481]
[PUBMED:10899310]
[PUBMED:9195132]
[PUBMED:7544001]
[PUBMED:7777534]
[PUBMED:12681450]
[PUBMED:7665592]
[PUBMED:8702919]
[PUBMED:1708096]
[PUBMED:8643566]
[PUBMED:7988557]
[PUBMED:7737351]
[PUBMED:1532814]
[PUBMED:8262551]
[PUBMED:8025955]
[PUBMED:10993906]
[PUBMED:3095922]
[PUBMED:8805624]
[PUBMED:9391116]
[PUBMED:7973658]
[PUBMED:11331873]
[PUBMED:10421845]
[PUBMED:8119884]
[PUBMED:7781605]
[PUBMED:12543077]
[PUBMED:9133424]
[PUBMED:1618313]
[PUBMED:1940342]
[PUBMED:9382798]
[PUBMED:10514520]
[PUBMED:7973659]
[PUBMED:1639773]
[PUBMED:9029085]
[PUBMED:7760801]
[PUBMED:1460037]
[PUBMED:9202126]
[PUBMED:1652056]
[PUBMED:12393431]
[PUBMED:8397196]
[PUBMED:2047859]
[PUBMED:7688728]
[PUBMED:8700888]
[PUBMED:7528668]
[PUBMED:9305919]
[PUBMED:2303462]
[PUBMED:7568001]
[PUBMED:9822600]
[PUBMED:7543676]
[PUBMED:7499365]
[PUBMED:10843677]
[PUBMED:7600304]
[PUBMED:7719937]
[PUBMED:9590209]
[PUBMED:9794391]
[PUBMED:10849428]
[PUBMED:8294403]
[PUBMED:10373548]
[PUBMED:2590941]
[PUBMED:9512511]
[PUBMED:6434688]
[PUBMED:9697832]
[PUBMED:10982827]
[PUBMED:10214954]
[PUBMED:10825200]
[PUBMED:1535827]
[PUBMED:10369681]
[PUBMED:7719938]
[PUBMED:1655887]
[PUBMED:8376945]
[PUBMED:1996324]
[PUBMED:7479881]
[PUBMED:10962581]
[PUBMED:7973657]
[PUBMED:1631559]
[PUBMED:10066828]
[PUBMED:9169478]
[PUBMED:8552611]
[PUBMED:8483935]
[PUBMED:2106566]
[PUBMED:16199887]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin Pathway
[NCBI:138026]
[Pathway Interaction Database:insulin_pathway]
[PUBMED:8491186]
[PUBMED:9111325]
[PUBMED:7629070]
[PUBMED:10499514]
[PUBMED:11121405]
[PUBMED:10660596]
[PUBMED:8196603]
[PUBMED:11096081]
[PUBMED:8524328]
[PUBMED:9891043]
[PUBMED:12242347]
[PUBMED:2123524]
[PUBMED:9369444]
[PUBMED:1375946]
[PUBMED:9348199]
[PUBMED:8826975]
[PUBMED:8316835]
[PUBMED:8999839]
[PUBMED:8449939]
[PUBMED:10807907]
[PUBMED:1599438]
[PUBMED:8265614]
[PUBMED:11171109]
[PUBMED:11821390]
[PUBMED:12687004]
[PUBMED:7806540]
[PUBMED:11154281]
[PUBMED:8244979]
[PUBMED:8798417]
[PUBMED:1381348]
[PUBMED:7581368]
[PUBMED:15787604]
[PUBMED:8385105]
[PUBMED:11551902]
[PUBMED:8114695]
[PUBMED:11997497]
[PUBMED:11001060]
[PUBMED:11309621]
[PUBMED:9109420]
[PUBMED:8383963]
[PUBMED:12147684]
[PUBMED:8144662]
[PUBMED:12036959]
[PUBMED:14734537]
[PUBMED:7983051]
[PUBMED:9083103]
[PUBMED:15210700]
[PUBMED:9065430]
[PUBMED:11297536]
[PUBMED:10544179]
[PUBMED:1321126]
[PUBMED:11502760]
[PUBMED:8978681]
[PUBMED:8999972]
[PUBMED:14690593]
[PUBMED:11832334]
[PUBMED:9447983]
[PUBMED:15192089]
[PUBMED:8524413]
[PUBMED:7685165]
[PUBMED:10329736]
[PUBMED:11287630]
[PUBMED:15486046]
[PUBMED:10330191]
[PUBMED:8626723]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Neurotrophic factor-mediated Trk receptor signaling
[NCBI:137977]
[Pathway Interaction Database:trkrpathway]
[PUBMED:1849459]
[PUBMED:8226808]
[PUBMED:11163269]
[PUBMED:7510697]
[PUBMED:11027277]
[PUBMED:15758069]
[PUBMED:11425862]
[PUBMED:11238898]
[PUBMED:11251075]
[PUBMED:8344249]
[PUBMED:9356464]
[PUBMED:11150291]
[PUBMED:10092678]
[PUBMED:1280261]
[PUBMED:11150334]
[PUBMED:11244088]
[PUBMED:10985348]
[PUBMED:15753086]
[PUBMED:1653651]
[PUBMED:11466412]
[PUBMED:15167895]
[PUBMED:1831195]
[PUBMED:10490030]
[PUBMED:8384556]
[PUBMED:16697063]
[PUBMED:17003042]
[PUBMED:15520226]
[PUBMED:15632082]
[PUBMED:16611639]
[PUBMED:16187212]
[PUBMED:9182757]
[PUBMED:1604323]
[PUBMED:16284401]
[PUBMED:8356095]
[PUBMED:10329710]
[PUBMED:9927421]
[PUBMED:9856458]
[PUBMED:10691301]
[PUBMED:1375038]
[PUBMED:10679771]
[PUBMED:15122257]
[PUBMED:15513915]
[PUBMED:16701206]
[PUBMED:1710174]
[PUBMED:8155326]
[PUBMED:8288573]
[PUBMED:7972023]
[PUBMED:7512734]
[PUBMED:10601297]
[PUBMED:16203995]
[PUBMED:12510192]
[PUBMED:16481401]
[PUBMED:8106527]
[PUBMED:11278445]
[PUBMED:9099755]
[PUBMED:1850821]
[PUBMED:9632781]
[PUBMED:10235685]
[PUBMED:15917464]
[PUBMED:9285826]
[PUBMED:12446789]
[PUBMED:7657612]
[PUBMED:1850549]
[PUBMED:12879077]
[PUBMED:16157584]
[PUBMED:10207144]
[PUBMED:12006576]
[PUBMED:8052307]
[PUBMED:8382740]
[PUBMED:10629055]
Oncogenic MAPK signaling
[NCBI:1457781]
[REACTOME:R-HSA-6802957]
[PUBMED:25907612]
[PUBMED:24651010]
[PUBMED:24202393]
[PUBMED:25435214]
[PUBMED:21993244]
[PUBMED:24814062]
[PUBMED:22589270]
PDGFR-beta signaling pathway
[NCBI:138071]
[Pathway Interaction Database:pdgfrbpathway]
[PUBMED:7545675]
[PUBMED:16769879]
[PUBMED:12652307]
[PUBMED:10463951]
[PUBMED:9742401]
[PUBMED:8086421]
[PUBMED:10391677]
[PUBMED:7739538]
[PUBMED:9989826]
[PUBMED:10734138]
[PUBMED:15753096]
[PUBMED:7692233]
[PUBMED:11489946]
[PUBMED:10837138]
[PUBMED:10229199]
[PUBMED:10821867]
[PUBMED:11709084]
[PUBMED:11389443]
[PUBMED:12958184]
[PUBMED:10734113]
[PUBMED:15161943]
[PUBMED:12149261]
[PUBMED:16456542]
[PUBMED:16224065]
[PUBMED:8619809]
[PUBMED:15494217]
[PUBMED:1849073]
[PUBMED:11085978]
[PUBMED:2544881]
[PUBMED:7622571]
[PUBMED:10779329]
[PUBMED:15944146]
[PUBMED:11027258]
[PUBMED:1708307]
[PUBMED:8940081]
[PUBMED:11854295]
[PUBMED:8195171]
[PUBMED:12424235]
[PUBMED:7935392]
[PUBMED:14966296]
[PUBMED:16537894]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
[NCBI:1383029]
[REACTOME:R-HSA-8849471]
[PUBMED:18829532]
[PUBMED:17483331]
[PUBMED:22084245]
[PUBMED:15572663]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Ras signaling pathway
[NCBI:868085]
[KEGG:hsa04014]
[PUBMED:23506953]
[PUBMED:18437264]
[PUBMED:15062121]
[PUBMED:22189424]
[PUBMED:22233291]
[PUBMED:12778136]
[PUBMED:11313946]
[PUBMED:17428555]
[PUBMED:19091743]
[PUBMED:18568040]
[PUBMED:20420946]
[PUBMED:12217381]
[PUBMED:14663478]
[PUBMED:21686117]
[PUBMED:12642680]
[PUBMED:21196257]
[PUBMED:16869784]
[PUBMED:21111786]
[PUBMED:16966426]
[PUBMED:10712923]
[PUBMED:22020205]
[PUBMED:17384584]
[PUBMED:15572660]
[PUBMED:18413813]
Regulation of RAS by GAPs
[NCBI:1269290]
[REACTOME:R-HSA-5658442]
[PUBMED:23443682]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by PTK6
[NCBI:1383025]
[REACTOME:R-HSA-8848021]
[PUBMED:15539407]
[PUBMED:15572663]
[PUBMED:25999240]
[PUBMED:20929863]
[PUBMED:23352614]
[PUBMED:20554524]
[PUBMED:23814047]
[PUBMED:21205088]
[PUBMED:18172307]
[PUBMED:25897081]
[PUBMED:18829532]
[PUBMED:24788754]
[PUBMED:25019382]
[PUBMED:8940083]
[PUBMED:19393627]
[PUBMED:18719096]
[PUBMED:22547065]
[PUBMED:21847121]
[PUBMED:19439179]
[PUBMED:22231447]
[PUBMED:25733683]
[PUBMED:20606012]
[PUBMED:18077133]
[PUBMED:15471878]
[PUBMED:20687930]
[PUBMED:23928995]
[PUBMED:16179349]
[PUBMED:26247733]
[PUBMED:11114724]
[PUBMED:17483331]
[PUBMED:22084245]
[PUBMED:10913193]
Signaling by RAS mutants
[NCBI:1457782]
[REACTOME:R-HSA-6802949]
[PUBMED:21993244]
[PUBMED:22589270]
[PUBMED:24651010]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling events mediated by focal adhesion kinase
[NCBI:169348]
[Pathway Interaction Database:fak_pathway]
[PUBMED:18793427]
[PUBMED:15340073]
[PUBMED:16054026]
[PUBMED:12932330]
[PUBMED:20038548]
[PUBMED:7542255]
[PUBMED:8939916]
[PUBMED:16000375]
[PUBMED:10856236]
[PUBMED:17164291]
[PUBMED:9148935]
[PUBMED:10893408]
[PUBMED:10512882]
[PUBMED:11839772]
[PUBMED:11553710]
[PUBMED:7566154]
[PUBMED:20018869]
[PUBMED:12839996]
[PUBMED:11799111]
[PUBMED:16308318]
[PUBMED:11331870]
[PUBMED:12681445]
[PUBMED:11369769]
[PUBMED:11739801]
[PUBMED:9860979]
[PUBMED:8947559]
[PUBMED:11017882]
[PUBMED:7509446]
[PUBMED:10791986]
[PUBMED:9128257]
[PUBMED:19297531]
[PUBMED:17325207]
[PUBMED:17093062]
[PUBMED:10593973]
[PUBMED:20308429]
[PUBMED:8922390]
[PUBMED:19776348]
[PUBMED:9374537]
[PUBMED:10976102]
[PUBMED:10373530]
[PUBMED:19883375]
[PUBMED:10430888]
[PUBMED:12820964]
[PUBMED:9425168]
[PUBMED:14743221]
[PUBMED:18854312]
[PUBMED:12952943]
[PUBMED:15962308]
[PUBMED:11927607]
[PUBMED:15657076]
[PUBMED:15039571]
[PUBMED:18303050]
[PUBMED:11799401]
[PUBMED:15247219]
[PUBMED:12702722]
[PUBMED:10998418]
[PUBMED:7615549]
[PUBMED:18195107]
[PUBMED:9032297]
[PUBMED:10873807]
[PUBMED:10777511]
[PUBMED:12502711]
[PUBMED:9566877]
[PUBMED:8649427]
[PUBMED:19473962]
[PUBMED:9808620]
[PUBMED:15914540]
[PUBMED:1385445]
[PUBMED:18223254]
[PUBMED:11909938]
[PUBMED:15166238]
[PUBMED:7622520]
[PUBMED:8824286]
[PUBMED:8662921]
[PUBMED:8707856]
[PUBMED:10330411]
[PUBMED:10446223]
[PUBMED:20150423]
[PUBMED:11604500]
[PUBMED:9234699]
[PUBMED:18773890]
[PUBMED:18757826]
[PUBMED:9864370]
[PUBMED:7983066]
[PUBMED:18322799]
[PUBMED:12006652]
[PUBMED:16461767]
[PUBMED:10385525]
[PUBMED:14676198]
[PUBMED:9858476]
[PUBMED:18070912]
[PUBMED:11058585]
[PUBMED:12890755]
[PUBMED:9184223]
[PUBMED:12058076]
[PUBMED:12226752]
[PUBMED:19435801]
[PUBMED:10212207]
[PUBMED:10521463]
[PUBMED:16159962]
[PUBMED:7579684]
[PUBMED:18362184]
[PUBMED:7997267]
[PUBMED:8816475]
[PUBMED:11279163]
[PUBMED:7537852]
[PUBMED:11418135]
[PUBMED:12167697]
[PUBMED:12615911]
[PUBMED:12876277]
Signaling events regulated by Ret tyrosine kinase
[NCBI:137915]
[Pathway Interaction Database:ret_pathway]
[PUBMED:11002419]
[PUBMED:17050626]
[PUBMED:11360177]
[PUBMED:7478523]
[PUBMED:12176011]
[PUBMED:12771945]
[PUBMED:14607833]
[PUBMED:7665556]
[PUBMED:8631863]
[PUBMED:11470823]
[PUBMED:15966897]
[PUBMED:12087092]
[PUBMED:16820412]
[PUBMED:15657578]
[PUBMED:10208419]
[PUBMED:9182757]
[PUBMED:8662982]
[PUBMED:9047383]
[PUBMED:12063395]
[PUBMED:15569713]
[PUBMED:15286081]
[PUBMED:10448070]
[PUBMED:16227613]
[PUBMED:11390647]
[PUBMED:15351743]
[PUBMED:8674117]
[PUBMED:11313948]
[PUBMED:2181380]
[PUBMED:9047384]
[PUBMED:8570170]
[PUBMED:11886862]
[PUBMED:9632781]
[PUBMED:16153436]
[PUBMED:11000521]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
Syndecan-2-mediated signaling events
[NCBI:138031]
[Pathway Interaction Database:syndecan_2_pathway]
[PUBMED:17623663]
[PUBMED:11373281]
[PUBMED:16357320]
[PUBMED:12507425]
[PUBMED:16945929]
[PUBMED:14976204]
[PUBMED:10772816]
[PUBMED:10843988]
[PUBMED:8528141]
[PUBMED:15936998]
[PUBMED:10734053]
[PUBMED:11179419]
[PUBMED:9660868]
[PUBMED:16198615]
[PUBMED:9660869]
[PUBMED:15752734]
[PUBMED:10446183]
[PUBMED:11580899]
[PUBMED:17548511]
[PUBMED:11931647]
[PUBMED:16139226]
[PUBMED:16008343]
[PUBMED:14527339]
[PUBMED:16997272]
[PUBMED:10639336]
[PUBMED:16440330]
[PUBMED:11018053]
[PUBMED:10704377]
[PUBMED:9244383]
[PUBMED:12860416]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR1 specific signals
[NCBI:137924]
[Pathway Interaction Database:vegfr1_pathway]
[PUBMED:9299537]
[PUBMED:9751730]
[PUBMED:9722576]
[PUBMED:14633857]
[PUBMED:11978735]
[PUBMED:11278319]
[PUBMED:12649282]
[PUBMED:16839566]
[PUBMED:12598525]
[PUBMED:12171920]
[PUBMED:12796773]
[PUBMED:16633338]
[PUBMED:11312102]
[PUBMED:9295307]
[PUBMED:10908731]
[PUBMED:16787925]
[PUBMED:11704645]
[PUBMED:9790910]
[PUBMED:10376602]
[PUBMED:9804796]
[PUBMED:11986311]
[PUBMED:10749680]
[PUBMED:12214271]
[PUBMED:9398617]
[PUBMED:8621427]
[PUBMED:11425855]
[PUBMED:15001553]
[PUBMED:10376603]
[PUBMED:7824266]
[PUBMED:10842181]
[PUBMED:9600074]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]
