full name
proprotein convertase subtilisin/kexin type 1

synonyms
BMIQ12, NEC1, PC1, PC3, SPC3, PCSK1, ENSG00000175426

HGNC
HGNC:8743

Entrez Gene
Gene:5122

ENSEMBL
ENSG00000175426

location
chr: 5
start: 95726040
stop: 95768985
strand: -

OMIM
OMIM:162150: PCSK1 (Sporadic)
OMIM:600955: Obesity with impaired prohormone processing
OMIM:612362: {Obesity, susceptibility to, BMIQ12}

transcripts
NM_000439.4
NM_001177875.1
NM_001177876.1

pathways
Incretin synthesis, secretion, and inactivation [NCBI:1268750] [REACTOME:R-HSA-400508] [PUBMED:19074620] [PUBMED:17498508] [PUBMED:17263764]
Insulin processing [NCBI:1268747] [REACTOME:R-HSA-264876] [PUBMED:11815450] [PUBMED:16714477] [PUBMED:16549443] [PUBMED:11815463] [PUBMED:9631292]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Peptide hormone biosynthesis [NCBI:1268753] [REACTOME:R-HSA-209952] [PUBMED:4368999]
Peptide hormone metabolism [NCBI:1268746] [REACTOME:R-HSA-2980736] [PUBMED:2663045] [PUBMED:21805235]
Synthesis, secretion, and deacylation of Ghrelin [NCBI:1268748] [REACTOME:R-HSA-422085] [PUBMED:19280057] [PUBMED:18396350]
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) [NCBI:1268751] [REACTOME:R-HSA-381771] [PUBMED:11564718] [PUBMED:17928588] [PUBMED:1499644] [PUBMED:17263764] [PUBMED:19074620] [PUBMED:17498508]
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) [NCBI:1268752] [REACTOME:R-HSA-400511] [PUBMED:19074620] [PUBMED:17498508] [PUBMED:17263764]