full name
lamin B1

synonyms
ADLD, LMN, LMN2, LMNB, LMNB1, ENSG00000113368

HGNC
HGNC:6637

Entrez Gene
Gene:4001

ENSEMBL
ENSG00000113368

location
chr: 5
start: 126112315
stop: 126172712
strand: +

OMIM
OMIM:150340: LMNB1 (Autosomal dominant inheritance)
OMIM:169500: Leukodystrophy, adult-onset, autosomal dominant

transcripts
NM_005573.3
NM_001198557.1

pathways
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Apoptotic cleavage of cellular proteins [NCBI:1270288] [REACTOME:R-HSA-111465] [PUBMED:17254298] [PUBMED:17599937] [PUBMED:12655297]
Apoptotic execution phase [NCBI:1270287] [REACTOME:R-HSA-75153] [PUBMED:12655297]
Breakdown of the nuclear lamina [NCBI:1270291] [REACTOME:R-HSA-352238] [PUBMED:12655297]
Caspase cascade in apoptosis [NCBI:137974] [Pathway Interaction Database:caspase_pathway] [PUBMED:7774019] [PUBMED:8626669] [PUBMED:9850096] [PUBMED:11803376] [PUBMED:15189451] [PUBMED:10564664] [PUBMED:9642276] [PUBMED:10567584] [PUBMED:12419244] [PUBMED:11423904] [PUBMED:9422506] [PUBMED:11438643] [PUBMED:9070648] [PUBMED:9588194] [PUBMED:11085743] [PUBMED:9298992] [PUBMED:9933635] [PUBMED:9528810] [PUBMED:9323209] [PUBMED:10809769] [PUBMED:8700869] [PUBMED:9463409] [PUBMED:10497198] [PUBMED:11953316] [PUBMED:9422513] [PUBMED:10409650] [PUBMED:11463840] [PUBMED:10611247] [PUBMED:8605870]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cellular Senescence [NCBI:1270426] [REACTOME:R-HSA-2559583] [PUBMED:21078816] [PUBMED:18711403] [PUBMED:22048312] [PUBMED:19818705] [PUBMED:17662938] [PUBMED:23746838] [PUBMED:9282108] [PUBMED:17667954] [PUBMED:13905658]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
DNA Damage/Telomere Stress Induced Senescence [NCBI:1270429] [REACTOME:R-HSA-2559586] [PUBMED:15790808] [PUBMED:15574587] [PUBMED:10669743] [PUBMED:9733515] [PUBMED:9357549] [PUBMED:8242751] [PUBMED:17694070] [PUBMED:2342578] [PUBMED:9733514] [PUBMED:10037601] [PUBMED:2392154] [PUBMED:9843217] [PUBMED:19528227] [PUBMED:16166375] [PUBMED:8242752]
Depolymerisation of the Nuclear Lamina [NCBI:1269819] [REACTOME:R-HSA-4419969] [PUBMED:23212477] [PUBMED:22134922] [PUBMED:2188730] [PUBMED:19494126] [PUBMED:8034666] [PUBMED:2188731] [PUBMED:21413788] [PUBMED:19494125] [PUBMED:2344612] [PUBMED:8463284] [PUBMED:22986494]
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models [NCBI:1457789] [REACTOME:R-HSA-8862803] [PUBMED:8090221] [PUBMED:12684440] [PUBMED:22899714] [PUBMED:10830966] [PUBMED:7592934] [PUBMED:19519302]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Formation of Senescence-Associated Heterochromatin Foci (SAHF) [NCBI:1270430] [REACTOME:R-HSA-2559584] [PUBMED:16901784] [PUBMED:17242207] [PUBMED:12809602] [PUBMED:17242198] [PUBMED:17643369] [PUBMED:19029251] [PUBMED:17158953] [PUBMED:15621527] [PUBMED:21807893] [PUBMED:11080164] [PUBMED:11025664] [PUBMED:10910364]
Initiation of Nuclear Envelope Reformation [NCBI:1269828] [REACTOME:R-HSA-2995383] [PUBMED:18628300] [PUBMED:19234477]
M Phase [NCBI:1269810] [REACTOME:R-HSA-68886]
Meiosis [NCBI:1269865] [REACTOME:R-HSA-1500620] [PUBMED:20051984] [PUBMED:20364103] [PUBMED:16543383] [PUBMED:18948708]
Meiotic synapsis [NCBI:1269867] [REACTOME:R-HSA-1221632] [PUBMED:20364103] [PUBMED:18948708]
Mitotic Anaphase [NCBI:1269825] [REACTOME:R-HSA-68882]
Mitotic Metaphase and Anaphase [NCBI:1269823] [REACTOME:R-HSA-2555396]
Mitotic Prophase [NCBI:1269811] [REACTOME:R-HSA-68875]
Neurodegenerative Diseases [NCBI:1457788] [REACTOME:R-HSA-8863678] [PUBMED:26848654]
Nuclear Envelope Breakdown [NCBI:1269815] [REACTOME:R-HSA-2980766] [PUBMED:19234477]
Nuclear Envelope Reassembly [NCBI:1269827] [REACTOME:R-HSA-2995410] [PUBMED:19234477]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]