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- CREB phosphorylation through the activation of CaMKII
description
Ca2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-induced transcription. The isoforms of adenylate cyclase that are activated by Ca2+ in the brain are I, III and IX
external resources
NCBI:1268805
REACTOME:R-HSA-442729
PUBMED:16799259
genes
ACTN2
,
CALM1
,
CALM2
,
CALM3
,
CAMK2A
,
CAMK2B
,
CAMK2D
,
CAMK2G
,
CREB1
,
DLG4
,
GRIN1
,
GRIN2A
,
GRIN2B
,
GRIN2C
,
GRIN2D
,
NEFL
,
AKAP9
,