description
Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons. Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons. Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin

external resources
NCBI:1268808
REACTOME:R-HSA-451326
PUBMED:18793656

genes
CALM1 , CALM2 , CALM3 , DLG1 , DLG3 , DLG4 , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , GRIK1 , GRIK2 , GRIK3 , GRIK4 , GRIK5 , PLCB2 , PLCB3 , GNB5 , PLCB1 , GNG13 , GNG2 , GNG12 , GNB4 , NCALD , GNG8 ,