description
Gamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate membrane depolarization and thus inhibit neurotransmitter release (G Michels et al Crit Rev Biochem Mol Biol 42, 2007, 3-14). GABA B receptors are slow acting metabotropic Gprotein coupled receptors that act via the inhibitory action of their Galpha/Go subunits on adenylate cyclase to attenuate the actions of PKA. In addition, their Gbeta/gamma subunits interact directly with N and P/Q Ca2+ channels to decrease the release of Ca2+. GABA B receptors also interact with Kir3 K+ channels and increase the influx of K+, leading to cell membrane hyperpolarization and inhibition of channels such as NMDA receptors (A Pinard et al Adv Pharmacol, 58, 2010, 231-55)
external resources
NCBI:1268813
REACTOME:R-HSA-977443
PUBMED:17364682
PUBMED:20655481
PUBMED:11283747
PUBMED:20655485
PUBMED:15269338
genes
ADCY1
,
ADCY2
,
ADCY3
,
ADCY5
,
ADCY6
,
ADCY7
,
ADCY8
,
ADCY9
,
GABBR1
,
GABRA1
,
GABRA2
,
GABRA3
,
GABRA4
,
GABRA5
,
GABRA6
,
GABRB1
,
GABRB2
,
GABRB3
,
GABRG2
,
GABRG3
,
GABRR1
,
GABRR2
,
GNAI1
,
GNAI2
,
GNAI3
,
GNAL
,
GNB1
,
GNB2
,
GNB3
,
GNG3
,
GNG4
,
GNG5
,
GNG7
,
GNG10
,
GNGT1
,
GNGT2
,
KCNJ2
,
KCNJ3
,
KCNJ4
,
KCNJ5
,
KCNJ6
,
KCNJ9
,
KCNJ10
,
KCNJ12
,
KCNJ15
,
KCNJ16
,
GABBR2
,
ARHGEF9
,
GNG2
,
GABRQ
,
GNG12
,
GNG8
,
ADCY4
,
GABRR3
,
GNAT3
,
MIR197
,
