description
Gamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate membrane depolarization and thus inhibit neurotransmitter release (G Michels et al Crit Rev Biochem Mol Biol 42, 2007, 3-14). GABA B receptors are slow acting metabotropic Gprotein coupled receptors that act via the inhibitory action of their Galpha/Go subunits on adenylate cyclase to attenuate the actions of PKA. In addition, their Gbeta/gamma subunits interact directly with N and P/Q Ca2+ channels to decrease the release of Ca2+. GABA B receptors also interact with Kir3 K+ channels and increase the influx of K+, leading to cell membrane hyperpolarization and inhibition of channels such as NMDA receptors (A Pinard et al Adv Pharmacol, 58, 2010, 231-55)

external resources
NCBI:1268813
REACTOME:R-HSA-977443
PUBMED:17364682
PUBMED:20655481
PUBMED:11283747
PUBMED:20655485
PUBMED:15269338

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , GABBR1 , GABRA1 , GABRA2 , GABRA3 , GABRA4 , GABRA5 , GABRA6 , GABRB1 , GABRB2 , GABRB3 , GABRG2 , GABRG3 , GABRR1 , GABRR2 , GNAI1 , GNAI2 , GNAI3 , GNAL , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNGT1 , GNGT2 , KCNJ2 , KCNJ3 , KCNJ4 , KCNJ5 , KCNJ6 , KCNJ9 , KCNJ10 , KCNJ12 , KCNJ15 , KCNJ16 , GABBR2 , ARHGEF9 , GNG2 , GABRQ , GNG12 , GNG8 , ADCY4 , GABRR3 , GNAT3 , MIR197 ,