description
Functional GABA B receptors are heteromers of GABA B1 and B2 subunits, complexed with G protein alpha-i, 0, beta, and gamma subunits. They function as metabotropic receptors. When GABA is bound to the B1 sub-unit, the B2 subunit undergoes a conformational change that releases the G alpha-i G0 dimer (which binds and inactivates cytosolic adenylate cyclase) and the G beta G gamma dimer (which activates the GIRK (KIR3) potassium channel) (Pinard et al. 2010)
external resources
NCBI:1268815
REACTOME:R-HSA-977444
PUBMED:20655485
genes
ADCY1
,
ADCY2
,
ADCY3
,
ADCY5
,
ADCY6
,
ADCY7
,
ADCY8
,
ADCY9
,
GABBR1
,
GNAI1
,
GNAI2
,
GNAI3
,
GNAL
,
GNB1
,
GNB2
,
GNB3
,
GNG3
,
GNG4
,
GNG5
,
GNG7
,
GNG10
,
GNGT1
,
GNGT2
,
KCNJ2
,
KCNJ3
,
KCNJ4
,
KCNJ5
,
KCNJ6
,
KCNJ9
,
KCNJ10
,
KCNJ12
,
KCNJ15
,
KCNJ16
,
GABBR2
,
GNG2
,
GNG12
,
GNG8
,
ADCY4
,
GNAT3
,
MIR197
,
