description
Functional GABA B receptors are heteromers of GABA B1 and B2 subunits, complexed with G protein alpha-i, 0, beta, and gamma subunits. They function as metabotropic receptors. When GABA is bound to the B1 sub-unit, the B2 subunit undergoes a conformational change that releases the G alpha-i G0 dimer (which binds and inactivates cytosolic adenylate cyclase) and the G beta G gamma dimer (which activates the GIRK (KIR3) potassium channel) (Pinard et al. 2010)

external resources
NCBI:1268815
REACTOME:R-HSA-977444
PUBMED:20655485

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , GABBR1 , GNAI1 , GNAI2 , GNAI3 , GNAL , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNGT1 , GNGT2 , KCNJ2 , KCNJ3 , KCNJ4 , KCNJ5 , KCNJ6 , KCNJ9 , KCNJ10 , KCNJ12 , KCNJ15 , KCNJ16 , GABBR2 , GNG2 , GNG12 , GNG8 , ADCY4 , GNAT3 , MIR197 ,