description
GABA B receptors are metabotropic receptors that are functionally linked to C type G protein coupled receptors.? GABA B receptors are activated upon ligand binding. The GABA B1 subunit binds ligand and GABA B2 subunit modulates the activity of adenylate cyclase via the intracellular loop.? GABA B receptors show inhibitory activity via Galpha/G0 subunits via the inhibition of adenylate cyclase or via the activity of Gbeta/gamma subunits that mediate the inhibition of voltage gated Ca2+ channels

external resources
NCBI:1268816
REACTOME:R-HSA-991365
PUBMED:20655481

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , GABBR1 , GNAI1 , GNAI2 , GNAI3 , GNAL , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNGT1 , GNGT2 , KCNJ2 , KCNJ3 , KCNJ4 , KCNJ5 , KCNJ6 , KCNJ9 , KCNJ10 , KCNJ12 , KCNJ15 , KCNJ16 , GABBR2 , GNG2 , GNG12 , GNG8 , ADCY4 , GNAT3 , MIR197 ,