description
GABA B receptors are coupled to Gproteins and function by increasing the K+ and decreasing the Ca2+ inside the cell. The increase in K+ increases the negative membrane potential of the cell thereby hyper polarizing the cell which inhibits the release of neurotransmitters. The decrease in Ca2+ also inhibits neurotransmitter in two ways; first by preventing the fusion of synaptic vesicles containing the neurotransmitter with the plasma membrane and second by decreasing the Ca2+ dependent recruitment of synaptic vesicles to the plasma membrane. In particular GABA B receptors inhibit voltage gated Ca2+ channels via the activity of Gbeta/Ggamma subunits of G proteins

external resources
NCBI:1268819
REACTOME:R-HSA-997272
PUBMED:20655481
PUBMED:20655490

genes
GABBR1 , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNGT1 , GNGT2 , KCNJ2 , KCNJ3 , KCNJ4 , KCNJ5 , KCNJ6 , KCNJ9 , KCNJ10 , KCNJ12 , KCNJ15 , KCNJ16 , GABBR2 , GNG2 , GNG12 , GNG8 ,