description
Inwardly rectifying K+ channels (Kir channels) show an inward rather than outward (like the voltage gated K+ channels) flow of K+ thereby contributing to maintenance of resting membrane potential and regulation of action potential in excitable tissue. Kir channels are found in a variety of cell types such as cardiac myocytes, neurons, blood cells, osteoblasts, glial cells, epithelial cells, and oocytes. Kir channels can be functionally divided into ATP sensitive K+ channels (Kir 6.1 and Kir 6.2), classical kir channels (Kir 2.1, 2.2, 2.3, 2.4, 5.1) G protein gated K+ channels (Kir 3.1, 3.2, 3.3, 3.4) and K+ transport channels (Kir1.1, 7.1, 4.2, 4.1)
external resources
NCBI:1268824
REACTOME:R-HSA-1296065
PUBMED:20086079
PUBMED:18087715
PUBMED:18691387
genes
GABBR1
,
GNB1
,
GNB2
,
GNB3
,
GNG3
,
GNG4
,
GNG5
,
GNG7
,
GNG10
,
GNGT1
,
GNGT2
,
KCNJ1
,
KCNJ2
,
KCNJ3
,
KCNJ4
,
KCNJ5
,
KCNJ6
,
KCNJ8
,
KCNJ9
,
KCNJ10
,
KCNJ11
,
KCNJ12
,
KCNJ14
,
KCNJ15
,
KCNJ16
,
ABCC8
,
GABBR2
,
ABCC9
,
GNG2
,
GNG12
,
GNG8
,
