description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways

external resources
NCBI:83055
KEGG:hsa04115
PUBMED:16557269
PUBMED:10714958
PUBMED:12505356
PUBMED:16915296
PUBMED:16697662
PUBMED:15116721
PUBMED:11313928
PUBMED:11747320
PUBMED:17409411
PUBMED:15838523

genes
APAF1 , FAS , ATM , ATR , ADGRB1 , BAX , CCND1 , BID , CASP3 , CASP8 , CASP9 , CCNB1 , CCND2 , CCND3 , CCNE1 , CCNG1 , CCNG2 , CDK1 , CDK2 , CDK4 , CDK6 , CDKN1A , CDKN2A , CHEK1 , DDB2 , GADD45A , SFN , IGF1 , IGFBP3 , CD82 , MDM2 , MDM4 , GADD45B , SERPINE1 , SERPINB5 , PMAIP1 , PTEN , RRM2 , SIAH1 , THBS1 , TP53 , TP73 , TSC2 , PPM1D , TNFRSF10B , CCNB2 , CCNE2 , EI24 , TP53I3 , GADD45G , CHEK2 , RCHY1 , BBC3 , SESN1 , RRM2B , SHISA5 , GTSE1 , CYCS , STEAP3 , PIDD1 , RPRM , TP53AIP1 , PERP , COP1 , ZMAT3 , SESN2 , CCNB3 , GORAB , SESN3 ,