description
Tandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mechanisms such as membrane stretch, pH, temperature. Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel)

external resources
NCBI:1268831
REACTOME:R-HSA-1296346
PUBMED:20393194
PUBMED:20529081

genes
KCNK1 , KCNK2 , KCNK3 , KCNK6 , KCNK7 , KCNK4 , KCNK9 , KCNK10 , KCNK13 , KCNK16 , KCNK17 , KCNK18 ,