description
Tandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mechanisms such as membrane stretch, pH, temperature. Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel)
external resources
NCBI:1268831
REACTOME:R-HSA-1296346
PUBMED:20393194
PUBMED:20529081
genes
KCNK1
,
KCNK2
,
KCNK3
,
KCNK6
,
KCNK7
,
KCNK4
,
KCNK9
,
KCNK10
,
KCNK13
,
KCNK16
,
KCNK17
,
KCNK18
,
