description
The transcriptional coactivator PPARGC1A (PGC-1alpha), one of the master regulators of mitochondrial biogenesis, is activated by phosphorylation. Energy depletion causes a reduction in ATP and an increase in AMP which activates AMPK. AMPK in turn phosphorylates PPARGC1A. Likewise, p38 MAPK is activated by muscle contraction (possibly via calcium and CaMKII) and phosphorylates PPARGC1A. PPARGC1A does not bind DNA directly, but rather interacts with other transcription factors. Deacetylation of PPARGC1A by SIRT1 appears to follow phosphorylation however the role of deacetylation is unresolved (Canto et al. 2009, Gurd et al. 2011, Philp et al. 2011

external resources
NCBI:1268840
REACTOME:R-HSA-2151209
PUBMED:19276888
PUBMED:19262508
PUBMED:20933024
PUBMED:21543634
PUBMED:21757760

genes
MAPK14 , PRKAA2 , PRKAB1 , PRKAB2 , PRKAG1 , MAPK11 , MAPK12 , PPARGC1A , PRKAG2 , PRKAG3 ,