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- Transcriptional activation of mitochondrial biogenesis
description
Phosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate the transcription of nuclear-encoded, mitochondrially targeted proteins such as TFB2M, TFB1M, and TFAM. PGC-1beta and PPRC appear to act similarly to PGC-1alpha but have not been as well studied. Transcription of PPARGC1A itself is upregulated by CREB1 (in response to calcium), MEF2C/D, ATF2, and PPARGC1A. Transcription of PPARGC1A is repressed by NR1D1 (REV-ERBA)
external resources
NCBI:1268841
REACTOME:R-HSA-2151201
PUBMED:22265687
PUBMED:20933024
PUBMED:19575678
PUBMED:22817841
PUBMED:19682549
genes
ALAS1
,
ATP5F1B
,
CREB1
,
ATF2
,
CREBBP
,
ESRRA
,
GABPA
,
GABPB1
,
HCFC1
,
MEF2C
,
MEF2D
,
NRF1
,
POLRMT
,
PPARA
,
MED1
,
RXRA
,
SMARCD3
,
SSBP1
,
TBL1X
,
TFAM
,
MTERF1
,
NCOA1
,
HDAC3
,
NR1D1
,
NCOR1
,
CARM1
,
NCOA2
,
PPARGC1A
,
POLG2
,
NCOA6
,
PPRC1
,
CRTC1
,
SIRT3
,
TFB1M
,
CYCS
,
GABPB1-IT1
,
TWNK
,
TFB2M
,
CRTC3
,
TBL1XR1
,
CHD9
,
HELZ2
,
TGS1
,
PPARGC1B
,
CRTC2
,