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description
Phosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate the transcription of nuclear-encoded, mitochondrially targeted proteins such as TFB2M, TFB1M, and TFAM. PGC-1beta and PPRC appear to act similarly to PGC-1alpha but have not been as well studied. Transcription of PPARGC1A itself is upregulated by CREB1 (in response to calcium), MEF2C/D, ATF2, and PPARGC1A. Transcription of PPARGC1A is repressed by NR1D1 (REV-ERBA)

external resources
NCBI:1268841
REACTOME:R-HSA-2151201
PUBMED:22265687
PUBMED:20933024
PUBMED:19575678
PUBMED:22817841
PUBMED:19682549

genes
ALAS1 , ATP5F1B , CREB1 , ATF2 , CREBBP , ESRRA , GABPA , GABPB1 , HCFC1 , MEF2C , MEF2D , NRF1 , POLRMT , PPARA , MED1 , RXRA , SMARCD3 , SSBP1 , TBL1X , TFAM , MTERF1 , NCOA1 , HDAC3 , NR1D1 , NCOR1 , CARM1 , NCOA2 , PPARGC1A , POLG2 , NCOA6 , PPRC1 , CRTC1 , SIRT3 , TFB1M , CYCS , GABPB1-IT1 , TWNK , TFB2M , CRTC3 , TBL1XR1 , CHD9 , HELZ2 , TGS1 , PPARGC1B , CRTC2 ,