description
Cilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core surrounded by a ring of nine microtubule triplets; the mother centriole additionally has 'distal' and 'subdistal appendages' that are critical for ciliogenesis (reviewed in Kim and Dynlacht, 2013; Firat-Karalar and Stearns, 2014; Bettencourt-Dias et al, 2011). Basal bodies initiate and anchor the extension of the axonemal microtubules and also associate with secretory vesicles which are thought to provide membrane components for the extension of the ciliary membrane (Sorokin, 1962; Sorokin, 1968; Bachmann-Gagescu et al, 2011; Tanos et al, 2013; reviewed in Ishikawa et al, 2011; Reiter et al, 2012). Basal bodies are attached to the plasma membrane through a proteinaceous network of transition fibers that form part of the 'transition zone' at the ciliary base. The transition zone acts as a selective barrier or ciliary pore, excluding vesicles and limiting the diffusion of proteins and lipids from the cytosol or plasma membrane (Deane et al, 2001; Craige et al, 2010; Garcia-Gonzalo et al, 2011; Ye et al, 2014; Joo et al, 2013; reviewed in Nachury et al, 2010; Hsiao et al, 2012; Reiter et al, 2012). In addition to the transition fibres, the transition zone also consists of the ciliary necklace (a row of protein particles at the ciliary membrane at the base of the cilium) and the Y-links (that connect the axonemal microtubules to the membrane at the ciliary necklace) (Williams et al, 2011; reviewed in Hsiao et al, 2012; Reiter et al, 2012)

external resources
NCBI:1268847
REACTOME:R-HSA-5620912
PUBMED:21816947
PUBMED:23747070
PUBMED:19575670
PUBMED:13978319
PUBMED:23348840
PUBMED:25047614
PUBMED:20819941
PUBMED:5661997
PUBMED:21422230
PUBMED:24469809
PUBMED:23530209
PUBMED:21725307
PUBMED:21680046
PUBMED:23351793
PUBMED:21427764
PUBMED:11676918
PUBMED:22653444

genes
CDK1 , CETN2 , CSNK1D , CSNK1E , DCTN1 , DYNC1H1 , DYNC1I2 , HSP90AA1 , RAB8A , SEPT2 , NEK2 , NPHP1 , ODF2 , PAFAH1B1 , PCM1 , PCNT , PLK1 , PPP2R1A , PRKACA , PRKAR2B , TUBA4A , TUBG1 , YWHAE , YWHAG , ALMS1 , TUBA1A , OFD1 , SSNA1 , DYNLL1 , RAB11A , IQCB1 , CEP135 , CEP57 , CCP110 , CKAP5 , SFI1 , ACTR1A , AKAP9 , TUBB4A , TUBB4B , DCTN2 , PLK4 , SDCCAG8 , CNTRL , FGFR1OP , CEP250 , DCTN3 , CEP162 , CEP164 , MAPRE1 , NINL , CEP131 , CEP152 , RPGRIP1L , CLASP1 , HAUS5 , C2CD3 , TCTN3 , B9D1 , CEP83 , TMEM216 , HAUS6 , AHI1 , NDE1 , MKS1 , HAUS4 , CEP192 , HAUS2 , HAUS7 , CEP72 , CDK5RAP2 , CENPJ , CC2D2A , MARK4 , HAUS3 , CEP97 , TCTN1 , TCTN2 , CEP76 , CEP290 , CEP63 , CEP70 , B9D2 , CEP78 , CEP89 , FBF1 , TMEM67 , HAUS8 , CEP41 , HAUS1 , RAB3IP , NEDD1 , SCLT1 , TTBK2 , TUBB , NPHP4 , KIF24 , MIR484 , MIR4707 ,