description
A number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of these cargo to the cilium (Mazelova et al, 2009; Geng et al, 2006; Jenkins et al, 2006; Ward et al, 2011; reviewed in Deretic, 2013). Although there is some support for the presence of a VxPx or related motif in the C-terminal tail of cargo destined for ARF4-mediated transport to the cilium, the details of this have not been definitively established and other ciliary targeting sequences have also been identified (reviewed in Deretic, 2013; Bhogaraju et al, 2013)

external resources
NCBI:1268849
REACTOME:R-HSA-5620916
PUBMED:23945166
PUBMED:16782012
PUBMED:16537653
PUBMED:23567335
PUBMED:21775626
PUBMED:19153612

genes
ARF4 , CNGB1 , CNGA2 , CNGA4 , RAB8A , PKD1 , PKD2 , RHO , GBF1 , RAB11A , RAB11FIP3 , EXOC5 , EXOC3 , EXOC7 , ASAP1 , EXOC6 , EXOC1 , EXOC2 , EXOC4 , RAB3IP , EXOC8 ,