description
EGFRvIII (EGFR V30_R297delinsG) is the most prevalent EGFR variant in glioblastoma, but it is also found in other cancer types. In-frame deletion of the ligand binding domain in EGFRvIII is frequently accompanied with genomic amplification, resulting in over-expression of EGFRvIII. EGFRvIII dimerizes and autophosphorylates spontaneously and is therefore constitutively active (Fernandes et al. 2001

external resources
NCBI:1268859
REACTOME:R-HSA-5637812
PUBMED:11087732

genes
CBL , EGF , EGFR , GAB1 , GRB2 , HRAS , HSP90AA1 , KRAS , NRAS , PIK3CA , PIK3R1 , PLCG1 , SHC1 , SOS1 , CDC37 , MIR1181 ,