description
NOTCH1 heterodimerization domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL) (Weng et al. 2004) and result in constitutive activity of NOTCH1 mutants (Malecki et al. 2006)

external resources
NCBI:1268886
REACTOME:R-HSA-2691230
PUBMED:15472075
PUBMED:16738328

genes
ADAM10 , JAG1 , JAG2 , NOTCH1 , RPS27A , ADAM17 , UBA52 , UBB , UBC , NEURL1 , DLL1 , NEURL1B , DLL4 , MIB1 , MIB2 ,