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description
NOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prolonged half-life of the intracellular NOTCH1 fragment, NICD1, and increased NICD1 transcriptional activity (Weng et al. 2004, Thompson et al. 2007, O'Neil et al. 2007)

external resources
NCBI:1268888
REACTOME:R-HSA-2644602
PUBMED:17646408
PUBMED:15472075
PUBMED:17646409

genes
ADAM10 , JAG1 , CCNC , CDK8 , CREBBP , EP300 , KAT2A , HDAC1 , HDAC2 , HES1 , RBPJ , JAG2 , MYC , NOTCH1 , PSEN2 , RPS27A , SKP1 , ADAM17 , TBL1X , UBA52 , UBB , UBC , CUL1 , HDAC3 , KAT2B , NEURL1 , NCOR1 , NCOR2 , HDAC9 , HDAC4 , MAML1 , RBX1 , HDAC6 , HDAC5 , MAMLD1 , SNW1 , NCSTN , HEY1 , HEY2 , HEYL , DLL1 , APH1A , HDAC7 , NEURL1B , DLL4 , FBXW7 , MAML3 , PSENEN , HDAC8 , MIB1 , TBL1XR1 , HDAC11 , APH1B , HDAC10 , MAML2 , MIB2 , HES5 , MIR1281 ,