description
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes

external resources
NCBI:83063
KEGG:hsa04340
PUBMED:22534646
PUBMED:26077918
PUBMED:24925320
PUBMED:23719536
PUBMED:26064136
PUBMED:26366162
PUBMED:20708941
PUBMED:22056910
PUBMED:18583599
PUBMED:23799571
PUBMED:26875496

genes
GRK2 , GRK3 , ARRB1 , ARRB2 , CCND1 , BCL2 , CCND2 , CSNK1A1 , CSNK1D , CSNK1E , CSNK1G2 , CSNK1G3 , EVC , GAS1 , GLI1 , GLI2 , GLI3 , GSK3B , IHH , LRP2 , PRKACA , PRKACB , PRKACG , PTCH1 , SHH , SMO , SPOP , CUL3 , CUL1 , PTCH2 , BTRC , KIF3A , FBXW11 , GPR161 , DHH , CDON , SUFU , CSNK1G1 , SMURF1 , HHIP , SMURF2 , BOC , CSNK1A1L , EVC2 , SPOPL , KIF7 ,