description
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling

external resources
NCBI:83066
KEGG:hsa04370
PUBMED:11741095
PUBMED:16104843
PUBMED:14641020
PUBMED:15338053
PUBMED:14724572
PUBMED:12391145
PUBMED:13678960
PUBMED:15602010

genes
AKT1 , AKT2 , BAD , CASP9 , CDC42 , MAPK14 , HRAS , HSPB1 , KDR , KRAS , NFATC2 , NOS3 , NRAS , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLA2G4A , PLCG1 , PLCG2 , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAPK11 , MAPK13 , MAP2K1 , MAP2K2 , PTGS2 , PTK2 , PXN , RAC1 , RAC2 , RAC3 , RAF1 , MAPK12 , SRC , VEGFA , MAPKAPK3 , PIK3R3 , PLA2G4C , JMJD7-PLA2G4B , SPHK1 , SH2D2A , MAPKAPK2 , AKT3 , SHC2 , SPHK2 , PLA2G4E , PLA2G4F , PLA2G4D , PLA2G4B ,