description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling

external resources
NCBI:83067
KEGG:hsa04510
PUBMED:10698680
PUBMED:15459662
PUBMED:14756624
PUBMED:11573199
PUBMED:12640026
PUBMED:15179030
PUBMED:15108811
PUBMED:15053919
PUBMED:11082269
PUBMED:15034601
PUBMED:12235283
PUBMED:14519391
PUBMED:11146675
PUBMED:11229600
PUBMED:15688067
PUBMED:14744429
PUBMED:11882383

genes
ACTB , ACTG1 , ACTN4 , ACTN1 , AKT1 , AKT2 , BIRC2 , BIRC3 , XIAP , RHOA , ARHGAP5 , BAD , CCND1 , BCL2 , BRAF , CAPN2 , CAV1 , CAV2 , CAV3 , CCND2 , CCND3 , CDC42 , CHAD , COL1A1 , COL1A2 , COL2A1 , COL4A1 , COL4A2 , COL4A3 , COL4A4 , COL4A5 , COL4A6 , COL6A1 , COL6A2 , COL6A3 , COL9A1 , COL9A2 , COL9A3 , COMP , CRK , CRKL , CTNNB1 , DIAPH1 , DOCK1 , EGF , EGFR , ELK1 , ERBB2 , VEGFD , FLNA , FLNB , FLNC , FLT1 , FLT4 , FN1 , FYN , GRB2 , RAPGEF1 , ARHGAP35 , GSK3B , HGF , HRAS , TNC , IBSP , IGF1 , IGF1R , ILK , ITGA6 , ITGA1 , ITGA2 , ITGA2B , ITGA3 , ITGA4 , ITGA5 , ITGA7 , ITGA9 , ITGAV , ITGB1 , ITGB3 , ITGB4 , ITGB5 , ITGB6 , ITGB7 , ITGB8 , JUN , KDR , LAMA2 , LAMA3 , LAMA4 , LAMA5 , LAMB1 , LAMB2 , LAMB3 , LAMC1 , LAMC2 , MET , MYL2 , MYL5 , MYLK , PPP1R12A , PPP1R12B , PAK1 , PAK2 , PAK3 , PDGFA , PDGFB , PDGFRA , PDGFRB , PDPK1 , PGF , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PPP1CA , PPP1CB , PPP1CC , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAPK8 , MAPK9 , MAPK10 , MAP2K1 , RELN , PTEN , PTK2 , PXN , RAC1 , RAC2 , RAC3 , RAF1 , RAP1A , RAP1B , RASGRF1 , ROCK1 , SHC1 , SOS1 , SOS2 , SPP1 , SRC , THBS1 , THBS2 , THBS3 , THBS4 , TLN1 , TNR , TNXB , VASP , VAV1 , VAV2 , VCL , VEGFA , VEGFB , VEGFC , VTN , VWF , ZYX , PIK3R3 , ITGA10 , ITGA8 , ROCK2 , BCAR1 , AKT3 , PAK4 , LAMC3 , MYL9 , VAV3 , MYL12A , LAMB4 , ITGA11 , PIP5K1C , SHC2 , PARVB , MYLPF , SHC3 , PPP1R12C , PARVA , PDGFC , PAK6 , PAK5 , MYL7 , TNN , PARVG , PDGFD , TLN2 , MYLK2 , MYLK3 , MYL10 , MYL12B , COL6A6 , COL6A5 , LAMA1 , MYLK4 , SHC4 ,