description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits

external resources
NCBI:83068
KEGG:hsa04512
PUBMED:7698997
PUBMED:15381249
PUBMED:12796473
PUBMED:11331578
PUBMED:15036264
PUBMED:12125070
PUBMED:12736199
PUBMED:15229478
PUBMED:11572082
PUBMED:10617638
PUBMED:12845610
PUBMED:12921709

genes
CD36 , CD44 , CD47 , CHAD , COL1A1 , COL1A2 , COL2A1 , COL4A1 , COL4A2 , COL4A3 , COL4A4 , COL4A5 , COL4A6 , COL6A1 , COL6A2 , COL6A3 , COL9A1 , COL9A2 , COL9A3 , COMP , DAG1 , FN1 , GP1BA , GP1BB , GP5 , GP9 , HMMR , HSPG2 , TNC , IBSP , ITGA6 , ITGA1 , ITGA2 , ITGA2B , ITGA3 , ITGA4 , ITGA5 , ITGA7 , ITGA9 , ITGAV , ITGB1 , ITGB3 , ITGB4 , ITGB5 , ITGB6 , ITGB7 , ITGB8 , LAMA2 , LAMA3 , LAMA4 , LAMA5 , LAMB1 , LAMB2 , LAMB3 , LAMC1 , LAMC2 , RELN , SDC1 , SDC4 , SPP1 , THBS1 , THBS2 , THBS3 , THBS4 , TNR , TNXB , VTN , VWF , ITGA10 , ITGA8 , SV2B , SV2A , LAMC3 , LAMB4 , ITGA11 , SV2C , GP6 , TNN , COL6A6 , COL6A5 , LAMA1 , AGRN ,