description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways

external resources
NCBI:83071
KEGG:hsa04530
PUBMED:25152334
PUBMED:16650994
PUBMED:22892070
PUBMED:18946474
PUBMED:12042308
PUBMED:23885123
PUBMED:16771626
PUBMED:17182900
PUBMED:21283798
PUBMED:25757376
PUBMED:22928510
PUBMED:22169974
PUBMED:25469537
PUBMED:24651541
PUBMED:15820555
PUBMED:17525755
PUBMED:27353478
PUBMED:17950242
PUBMED:18005931
PUBMED:24548561
PUBMED:21781017
PUBMED:20094051
PUBMED:20134025
PUBMED:22896795
PUBMED:18094055
PUBMED:25483301

genes
ACTB , ACTG1 , ACTN4 , ACTN1 , RHOA , CCND1 , CACNA1D , RUNX1 , CD1A , CD1B , CD1C , CD1D , CD1E , CDC42 , CDK4 , CFTR , CLDN4 , CLDN3 , CLDN7 , DLG1 , DLG2 , DLG3 , CTTN , ERBB2 , GATA4 , HCLS1 , HSPA4 , ITGB1 , JUN , LLGL2 , LLGL1 , MAP3K1 , MAP3K5 , RAB8A , AFDN , MSN , MYH1 , MYH2 , MYH3 , MYH4 , MYH8 , MYH9 , MYH10 , MYH11 , MYL2 , MYL6 , NEDD4 , NF2 , CLDN11 , PCNA , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R2A , PPP2R2B , PPP2R2C , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKACA , PRKACB , PRKACG , PRKAG1 , PRKCE , PRKCI , PRKCZ , MAPK8 , MAPK9 , MAPK10 , MAP2K7 , RAB13 , RAC1 , RAP1A , RDX , ROCK1 , SRC , STK11 , TIAM1 , TJP1 , CLDN5 , TUBA4A , TUBA3C , VASP , EZR , WAS , TUBA1A , SYMPK , YBX3 , MYH13 , MPDZ , WASL , CLDN10 , CLDN8 , CLDN6 , CLDN2 , CLDN1 , CLDN9 , ARHGEF2 , MAGI1 , SLC9A3R1 , TJP2 , ROCK2 , RAPGEF2 , ACTR3 , ACTR2 , PATJ , TUBA1B , MYL9 , MYL12A , CLDN16 , BVES , SYNPO , MYH15 , NEDD4L , ARHGEF18 , SCRIB , CLDN14 , CLDN15 , CLDN17 , TJP3 , CLDN20 , F11R , PARD6A , CLDN18 , AMOTL2 , PRKAG2 , RAPGEF6 , RAB8B , TUBA8 , PRKAG3 , CLDN22 , EPB41L4B , ARHGAP17 , PPP2R2D , PARD3 , ACTR3B , CGN , MYH7B , RAP2C , JAM2 , MPP4 , MPP5 , MICALL2 , MYH14 , TUBAL3 , JAM3 , PARD6G , PARD6B , TUBA1C , CGNL1 , MARVELD3 , CRB3 , TJAP1 , MYL12B , TUBA3E , TUBA3D , WHAMM , CLDN23 , MYL6B , CLDN19 , IGSF5 , MARVELD2 , AMOT , AMOTL1 , CLDN25 , ACTR3C , CLDN24 , OCLN ,