description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation

external resources
NCBI:83072
KEGG:hsa04540
PUBMED:9535909
PUBMED:15033578
PUBMED:12566218
PUBMED:14506308
PUBMED:10751659
PUBMED:10873290
PUBMED:15955302
PUBMED:15033579
PUBMED:15033580
PUBMED:15094344

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ADRB1 , CDK1 , CSNK1D , DRD1 , DRD2 , LPAR1 , EGF , EGFR , GJA1 , GNA11 , GNAI1 , GNAI2 , GNAI3 , GNAQ , GNAS , GRB2 , GRM1 , GRM5 , GUCY1A2 , GUCY1A1 , GUCY1B1 , HRAS , HTR2A , HTR2B , HTR2C , ITPR1 , ITPR2 , ITPR3 , KRAS , NRAS , PDGFA , PDGFB , PDGFRA , PDGFRB , PLCB2 , PLCB3 , PLCB4 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , PRKG1 , PRKG2 , MAPK1 , MAPK3 , MAPK7 , MAP2K1 , MAP2K2 , MAP2K5 , RAF1 , SOS1 , SOS2 , SRC , TJP1 , TUBA4A , TUBA3C , TUBB2A , TUBA1A , TUBA1B , TUBB3 , TUBB4A , TUBB4B , MAP3K2 , PLCB1 , TUBA8 , PDGFC , GJD2 , TUBAL3 , PDGFD , TUBB1 , TUBB6 , TUBA1C , TUBA3E , TUBA3D , ADCY4 , TUBB , TUBB8 , TUBB2B ,