description
The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning

external resources
NCBI:83073
KEGG:hsa04610
PUBMED:23564577
PUBMED:25309880
PUBMED:26082779
PUBMED:23110467
PUBMED:20027185
PUBMED:25568220
PUBMED:26324800
PUBMED:25705421
PUBMED:21811895
PUBMED:23911436
PUBMED:23564578
PUBMED:24924409
PUBMED:26489954
PUBMED:17635716

genes
A2M , SERPINC1 , BDKRB1 , BDKRB2 , CFB , SERPING1 , C1QA , C1QB , C1QC , C1R , C1S , C2 , C3 , C3AR1 , C4A , C4B , C4BPA , C4BPB , C5 , C5AR1 , C6 , C7 , C8A , C8B , C8G , C9 , CD59 , CLU , CPB2 , CR1 , CR2 , CD55 , CFD , F2 , F2R , F2RL2 , F3 , F5 , F7 , F8 , F9 , F10 , F11 , F12 , F13A1 , F13B , FGA , FGB , FGG , SERPIND1 , CFH , CFI , ITGAM , ITGAX , ITGB2 , KLKB1 , KNG1 , MBL2 , CD46 , SERPINE1 , SERPINB2 , SERPINA5 , SERPINA1 , PLAT , PLAU , PLAUR , PLG , SERPINF2 , PROC , PROS1 , MASP1 , TFPI , THBD , VTN , VWF , F2RL3 , PROCR , MASP2 , VSIG4 ,