description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors

external resources
NCBI:83077
KEGG:hsa04630
PUBMED:21034406
PUBMED:22339650
PUBMED:16204702
PUBMED:25587654
PUBMED:24069565
PUBMED:22383755
PUBMED:24606160
PUBMED:10851053
PUBMED:23735217
PUBMED:25217450
PUBMED:21372217

genes
AKT1 , AKT2 , AOX1 , CCND1 , BCL2 , BCL2L1 , CCND2 , CCND3 , CDKN1A , CISH , CNTF , CNTFR , CREBBP , CSF2 , CSF2RA , CSF2RB , CSF3 , CSF3R , CSH1 , CSH2 , CTF1 , EP300 , EPO , EPOR , FHL1 , MTOR , GFAP , GH1 , GH2 , GHR , GRB2 , HRAS , IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 , IFNAR1 , IFNAR2 , IFNB1 , IFNG , IFNGR1 , IFNGR2 , IFNW1 , IL2 , IL2RA , IL2RB , IL2RG , IL3 , IL3RA , IL4 , IL4R , IL5 , IL5RA , IL6 , IL6R , IL6ST , IL7 , IL7R , IL9 , IL9R , IL10 , IL10RA , IL10RB , IL11 , IL11RA , IL12A , IL12B , IL12RB1 , IL12RB2 , IL13 , IL13RA1 , IL13RA2 , IL15 , IL15RA , JAK1 , JAK2 , JAK3 , LEP , LEPR , LIF , LIFR , MCL1 , MPL , MYC , OSM , PIK3CA , PIK3CB , PIM1 , PIK3CD , PIK3R1 , PIK3R2 , PRL , PRLR , PTPN2 , PTPN6 , PTPN11 , RAF1 , SOS1 , SOS2 , STAT1 , STAT2 , STAT3 , STAT4 , STAT5A , STAT5B , STAT6 , THPO , TYK2 , STAM , PIK3R3 , PIAS1 , SOCS1 , SOCS2 , SOCS3 , PIAS2 , OSMR , SOCS6 , IL27RA , SOCS5 , AKT3 , STAM2 , IRF9 , PIAS3 , IL24 , IL19 , SOCS7 , IL20 , IL21R , IL22 , IL23A , PIAS4 , IL17D , IL20RA , IL20RB , IFNK , IL22RA1 , IL21 , CRLF2 , TSLP , IL22RA2 , SOCS4 , IL23R , IFNLR1 , IFNL2 , IFNL3 , IFNL1 , IFNE ,