description
In the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation is incomplete with non-processive polymerases disengaging from the proviral DNA template prematurely (reviewed in Karn 1999). The mechanism of Tat-mediated elongation is described below

external resources
NCBI:1269074
REACTOME:R-HSA-167169
PUBMED:10550206
PUBMED:15049426

genes
CCNH , CCNT1 , CDK7 , CDK9 , ERCC2 , ERCC3 , GTF2F1 , GTF2F2 , GTF2H1 , GTF2H2 , GTF2H3 , GTF2H4 , MNAT1 , NCBP1 , POLR2A , POLR2B , POLR2C , POLR2D , POLR2E , POLR2F , POLR2G , POLR2H , POLR2I , POLR2J , POLR2K , POLR2L , SSRP1 , SUPT4H1 , SUPT5H , TCEA1 , ELOC , ELOB , ELOA , NELFA , NELFE , ELL , CTDP1 , SUPT16H , NCBP2 , NELFB , ELOA2 , NELFCD , ELOA3 , GTF2H5 , ELOA3B , MIR943 , MIR1236 , MIR2861 , ELOA3D , MIR3960 ,