description
This event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of the HIV-1 Tat protein, the RNA Pol II complexes associated with the HIV-1 template are non-processive. RNA Pol II is arrested after promoter clearance by the negative transcriptional elongation factors DSIF and NELF as occurs during early elongation of endogenous templates (Wada et al, 1998; Yamaguchi et al. 1999). This arrest cannot be overcome by P-TEFb mediated phosphorylation in the absence of Tat however, and elongation aborts resulting in the accumulation of short transcripts (Kao et al., 1987)

external resources
NCBI:1269078
REACTOME:R-HSA-167242
PUBMED:2825027
PUBMED:9450929
PUBMED:10199401

genes
GTF2F1 , GTF2F2 , NCBP1 , POLR2A , POLR2B , POLR2C , POLR2D , POLR2E , POLR2F , POLR2G , POLR2H , POLR2I , POLR2J , POLR2K , POLR2L , SUPT4H1 , SUPT5H , NELFA , NELFE , CTDP1 , NCBP2 , NELFB , NELFCD , MIR943 , MIR1236 ,