description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes

external resources
NCBI:83081
KEGG:hsa04662
PUBMED:15626471
PUBMED:12119152
PUBMED:15886119
PUBMED:12461567
PUBMED:9697839
PUBMED:15752555
PUBMED:11163197
PUBMED:18086859
PUBMED:15364057
PUBMED:15457440
PUBMED:15322145
PUBMED:15771577
PUBMED:12033741
PUBMED:15886112
PUBMED:10358768

genes
AKT1 , AKT2 , BTK , CD19 , CD22 , CD72 , CD79A , CD79B , CD81 , CHUK , CR2 , FCGR2B , FOS , GRB2 , GSK3B , HRAS , IKBKB , INPP5D , INPPL1 , JUN , KRAS , LYN , NFATC1 , NFATC2 , NFATC3 , NFKB1 , NFKBIA , NFKBIB , NFKBIE , NRAS , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLCG2 , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , PRKCB , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , PTPN6 , RAC1 , RAC2 , RAC3 , RAF1 , RELA , SOS1 , SOS2 , SYK , VAV1 , VAV2 , PIK3R3 , IKBKG , IFITM1 , BCL10 , AKT3 , VAV3 , MALT1 , LILRB3 , RASGRP3 , DAPP1 , BLNK , CARD11 , PIK3AP1 ,