Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin beta-B23 complex associates with the nuclear pore through interactions between importin beta and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin beta resulting in in the disassembly of the importin beta-Rev-B23 complex and the release of Rev cargo

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RCC1 , KPNB1 , NPM1 , NUP88 , NUP98 , RAN , RANBP2 , TPR , NUP214 , AAAS , RAE1 , NUP155 , NUP93 , NUP58 , POM121 , NUP153 , NUP50 , NUPL2 , NUP205 , NUP210 , NUP160 , NUP188 , NUP62 , NUP54 , NDC1 , NUP133 , NUP107 , NUP37 , NUP85 , SEH1L , NUP35 , NUP43 , POM121C ,