description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses

external resources
NCBI:83082
KEGG:hsa04664
PUBMED:16470226
PUBMED:12145654
PUBMED:11079101
PUBMED:10586892
PUBMED:14630197
PUBMED:12360215
PUBMED:11449275

genes
AKT1 , AKT2 , ALOX5 , ALOX5AP , BTK , MAPK14 , CSF2 , FCER1A , MS4A2 , FCER1G , FYN , GRB2 , HRAS , IL3 , IL4 , IL5 , IL13 , INPP5D , KRAS , LCP2 , LYN , NRAS , PDPK1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLA2G4A , PLCG1 , PLCG2 , PRKCA , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , MAP2K1 , MAP2K2 , MAP2K3 , MAP2K6 , MAP2K7 , RAC1 , RAC2 , RAC3 , RAF1 , MAPK12 , MAP2K4 , SOS1 , SOS2 , SYK , TNF , VAV1 , VAV2 , PIK3R3 , PLA2G4C , JMJD7-PLA2G4B , GAB2 , AKT3 , VAV3 , LAT , PLA2G4E , PLA2G4F , PLA2G4D , PLA2G4B ,