description
The toxic effects of many bacteria on their human hosts are mediated by proteins released from the bacteria that enter human cells and disrupt critical cellular functions (Henkel et al. 2010). All of the ones annotated here share a bipartiite mechanism of host intoxication: one moiety binds target cells and mediates the delivery of the other part to the intracellular compartment where it can function as an enzyme to degrade or derivatize and inactivate critical target cell proteins or to activate constitutive synthesis of high levels of cAMP

external resources
NCBI:1269144
REACTOME:R-HSA-5339562
PUBMED:20358680

genes
CALM1 , CALM2 , CALM3 , CD9 , HBEGF , EEF2 , GUCY2C , HSP90AA1 , HSP90AB1 , FURIN , MAP2K1 , MAP2K2 , MAP2K3 , MAP2K6 , MAP2K7 , MAP2K4 , SNAP25 , STX1A , VAMP1 , VAMP2 , SYT1 , TXNRD1 , SV2B , SV2A , PDCD6IP , SV2C , PDZD3 , ANTXR1 , STX1B , ANTXR2 , SYT2 ,