description
Botulinum toxin type F (BoNT/F) is only very rarely associated with human disease (Hatheway 1995) and a pathway by which it might enter the circulation from the human gut has not been described. Nevertheless, the toxin itself, a disulfide-bonded heavy chain (HC) - light chain (LC) heterodimer ("dichain"), is capable of binding to neurons by interactions with cell-surface ganglioside and synaptic vesicle protein 2 (SV2) (Fu et al. 2009; Rummel et al. 2009), the bound toxin can enter synaptic vesicles and release its LC moiety into the cytosol of targeted cells (Montal 2010), and the BoNT/F LC can cleave vesicle-associated membrane proteins 1 and 2 (VAMP1 and 2) on the cytosolic face of the synaptic vesicle membrane (Yamasaki et al. 1994). These four events are annotated here

external resources
NCBI:1269152
REACTOME:R-HSA-5250981
PUBMED:20233039
PUBMED:8175689
PUBMED:19650874
PUBMED:8542759
PUBMED:19476346

genes
VAMP1 , VAMP2 , SV2B , SV2A , SV2C ,