description
Botulinum toxin type G (BoNT/G) is rarely if ever associated with human disease (Hatheway 1995) and a pathway by which it might enter the circulation from the human gut has not been described. Nevertheless, the toxin itself, a disulfide-bonded heavy chain (HC) - light chain (LC) heterodimer ("dichain"), is capable of binding to neurons by interactions with cell-surface ganglioside and syntagmin 1 (SYT1) (Peng et al. 2012; Willjes et al. 2013), the bound toxin can enter synaptic vesicles and release its LC moiety into the cytosol of targeted cells (Montal 2010), and the BoNT/F LC can cleave vesicle-associated membrane proteins 1 and 2 (VAMP1 and 2) on the cytosolic face of the synaptic vesicle membrane (Schiavo et al. 1994; Yamasaki et al. 1994). These four events are annotated here

external resources
NCBI:1269153
REACTOME:R-HSA-5250989
PUBMED:20233039
PUBMED:23647335
PUBMED:22454523
PUBMED:8542759
PUBMED:7910017
PUBMED:8051110

genes
VAMP1 , VAMP2 , SYT1 ,