description
The immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may present itself as either overactivity or underactivity of the immune system leading to a broad spectrum of clinical phenotypes that can be categorized into four main groups - autoimmunity, immunodeficiency (ID) with a greater susceptibility to infectious diseases, hypersensitivity to compounds that are usually not harmful and malignancy. Several host conditions may cause the dysfunctional immunity. Among them are inherited and somatic mutations found in the components of immune signaling pathways. In addition to genetic defects, infection with pathogen such as human immunodeficiency virus (HIV), or interaction of immune cells with immunosuppressive drugs result in non-genetic immunodeficiencies. Age-associated alterations in immunity may also contribute to pathogenesis of immunodeficiency .The Reactome module represents selected defects of the immune system and provides a short description of their clinical phenotypes. The module also describes functional features of defective molecules by both providing a published source for experimental functional analysis data and linking to the corresponding normal process within the Reactome database

external resources
NCBI:1269156
REACTOME:R-HSA-5260271
PUBMED:24795713
PUBMED:22165913

genes
BTK , CD14 , CD36 , CHUK , IKBKB , MYD88 , NFKB1 , NFKB2 , NFKBIA , NFKBIB , RELA , TLR1 , TLR2 , TLR3 , TLR4 , TLR5 , TRAF3 , IKBKG , TLR6 , LY96 , IRAK4 , TLR10 , TIRAP , TICAM1 ,