description
Inborn errors of interferon immunity due to defects in toll like receptor 3 (TLR3)-mediated signaling underlie pathogenesis of herpes simplex virus type 1 (HSV1) encephalitis (HSE) in some children (Netea MG et al. 2012). Autosomal dominant (AD) and recessive (AR) deficiencies of (TIR) domain-containing adaptor inducing IFN-beta (TRIF or TICAM1) are also associated with impaired IFN production and predisposition to HSE in the course of primary infection by HSV1 (Sancho-Shimizu V et al. 2011)

external resources
NCBI:1269164
REACTOME:R-HSA-5602566
PUBMED:22105173

genes
TLR3 , TICAM1 ,