description
TNF Receptor Associated Factor 3 (TRAF3) is a cytoplasmic adaptor protein utilized by the tumor necrosis factor receptor superfamily and toll-like receptors (TLRs). TRAF3 deficiency is thought to mimic the previously reported TLR3 deficiency in terms of susceptibility to herpes simplex virus type 1 (HSV1) encephalitis (HSE) via impaired TLR3-mediated immunity against HSV1 infection of central nervous system (CNS) (P?rez de Diego R et al. 2010; Guo Y et al. 2011)

external resources
NCBI:1269165
REACTOME:R-HSA-5602571
PUBMED:20832341

genes
TLR3 , TRAF3 , TICAM1 ,