description
Adaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with remarkable diversity tailored to recognize aspects of particular pathogens or antigens. During infection, dendritic cells (DC) which act as sentinels in the peripheral tissues recognize and pick up the pathogen in the form of antigenic determinants and then process these antigens and present them to T cells. These T cells of appropriate specificity respond to the antigen, and either kill the pathogen directly or secrete cytokines that will stimulate B lymphocyte response. B cells provide humoral immunity by secreting antibodies specific for the pathogen or antigen

external resources
NCBI:1269171
REACTOME:R-HSA-1280218
PUBMED:16551257
PUBMED:21682741
PUBMED:11861602

genes
AP2A1 , AP2A2 , AP1B1 , AP2B1 , AP1G1 , AKT1 , AKT2 , ARF1 , B2M , BAD , BLK , BLMH , BTC , BTK , BTN1A1 , C3 , CALM1 , CALM2 , CALM3 , CALR , CANX , CASP9 , CBL , CBLB , CCNF , CD1A , CD1B , CD1C , CD1D , CD3D , CD3E , CD3G , CD247 , CD4 , CD8A , CD8B , CD14 , CD19 , CD22 , CD28 , CD80 , CD86 , CD33 , SIGLEC6 , CD34 , CD36 , CD40 , CD40LG , CD74 , CD79A , CD79B , CD81 , CDC20 , CDC27 , CDC34 , CDC42 , CDH1 , CDKN1A , CDKN1B , CENPE , CTSC , CHUK , AP2M1 , AP1S1 , AP2S1 , CLTA , CLTC , MAP3K8 , CREB1 , CSK , CTLA4 , CTSB , CTSD , CTSE , CTSH , CTSK , CTSL , CTSV , CTSO , CTSS , CXADR , CYBA , CYBB , DCTN1 , DNM1 , DYNC1H1 , DYNC1I1 , DYNC1I2 , DYNC1LI2 , DNM2 , HBEGF , EGF , EGFR , ERBB2 , ERBB3 , ERBB4 , EREG , FCGR1A , FCGR1B , FCGR2B , FCGR3A , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , FOXO1 , FOXO3 , MTOR , FYB1 , FYN , GAB1 , GRB2 , PDIA3 , GSK3A , GSK3B , HGF , NRG1 , UBE2K , HLA-A , HLA-B , HLA-C , HLA-DMA , HLA-DMB , HLA-DOA , HLA-DOB , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DQB2 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , HLA-E , HLA-F , HLA-G , HLA-H , NR4A1 , HRAS , HSPA5 , ICAM1 , ICAM2 , ICAM3 , ICAM4 , IGLC1 , IGLC6 , IKBKB , INS , INPP5D , INSR , IRS1 , ITGA4 , ITGAL , ITGAV , ITGB1 , ITGB2 , ITGB5 , ITGB7 , ITK , ITPR1 , ITPR2 , ITPR3 , KIF2A , KIF3C , KIF5A , KIF5B , KIR2DL1 , KIR2DL3 , KIR2DL4 , KIR3DL1 , KIR3DL2 , KIT , KLRB1 , KLRC1 , KLRD1 , KLC1 , KIF11 , KIF22 , KRAS , LAG3 , LAIR1 , LAIR2 , LCK , LCP2 , LMO7 , LNPEP , LYN , SH2D1A , MDM2 , MET , KITLG , MICB , FOXO4 , MOV10 , CD200 , MRC1 , TRIM37 , MYD88 , NCF2 , NCF4 , NCK1 , NEDD4 , NFKB1 , NFKBIA , NFKBIB , NFKBIE , NRAS , PAK1 , PAK2 , PAK3 , PRKN , PDCD1 , PDGFA , PDGFB , PDGFRA , PDGFRB , PDPK1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PIP4K2A , PLCG1 , PLCG2 , CTSA , PPL , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , PRKACA , PRKACB , PRKACG , PRKCB , PRKCQ , PRKG1 , MAPK1 , MAPK3 , LGMN , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTEN , PTPN6 , PTPN11 , PTPRC , PTPRJ , PVR , NECTIN2 , RAC1 , RAF1 , RAP1A , RAP1B , RAP1GAP , RBBP6 , REL , RELA , RNF4 , RNF6 , RPS6KB2 , RPS27A , SEC13 , SELL , SH3GL2 , SHC1 , FBXW4 , SIAH1 , SIAH2 , SIPA1 , SKP1 , SKP2 , SIGLEC1 , SOS1 , SPTBN2 , SRC , SRMS , TRIM21 , STIM1 , STX4 , SYK , MAP3K7 , TAP1 , TAP2 , TAPBP , ELOC , ELOB , ICAM5 , TLR1 , TLR2 , TLR4 , TP53 , TPP2 , TRAF6 , TRPC1 , TSC2 , TYROBP , UBA52 , UBB , UBC , UBA1 , UBA7 , UBE2A , UBE2B , UBE2D1 , UBE2D2 , UBE2D3 , UBE2E1 , UBE2E2 , UBE2G1 , UBE2G2 , UBE2H , UBE2L3 , UBE2N , UBE2V1 , UBE2V2 , UBE3A , VASP , VAV1 , VCAM1 , VHL , WAS , XDH , YES1 , YWHAB , YWHAZ , ZAP70 , ZBTB16 , RAB7A , SEM1 , CUL5 , FGF23 , GAN , MADCAM1 , PIP5K1A , PIP5K1B , PIP4K2B , CUL3 , CUL2 , CUL1 , PIK3R3 , IKBKG , IFITM1 , SOCS1 , DYNLL1 , IRS2 , VAMP8 , CDC23 , CTSF , TNFRSF14 , RIPK2 , SNAP23 , SIGLEC5 , FGF18 , FGF17 , FGF16 , IER3 , CDC16 , AP1S2 , AP1M1 , BCL10 , HERC3 , HERC2 , HERC1 , BTRC , MAP3K14 , SOCS3 , UBA3 , UBE2M , UBE2L6 , TRIP12 , VAMP3 , UBE4A , KL , KIF3B , CD101 , GRAP2 , NCR2 , NCR1 , PSMF1 , KIF23 , NPEPPS , NRG2 , RNF14 , RNF7 , SEC24C , DZIP3 , UBE3C , DCAF1 , KEAP1 , CUL7 , PSMD6 , PJA2 , AREL1 , SEC24D , MRC2 , KLHL21 , FGF19 , CLEC2B , RBX1 , AKT3 , AP1M2 , HUWE1 , KIF20A , ACTR1B , ACTR1A , RASGRP1 , RNF41 , PSME3 , PSMD14 , KLRG1 , CD96 , RASGRP2 , STUB1 , LILRB2 , TRAIP , KLHL41 , TLR6 , BTN3A3 , BTN2A2 , ANAPC10 , RAPGEF3 , UBAC1 , ARIH2 , SEC24B , IFI30 , UBE2E3 , SEC23A , LRRC41 , FBXW10 , ATG7 , DCTN2 , RBCK1 , CD226 , DCTN6 , NRG3 , AHCYL1 , SEC24A , FRS2 , LILRB1 , HCST , CD300C , MALT1 , SEC61B , LILRB5 , KIF2C , LILRB4 , LILRA1 , LILRB3 , LILRA3 , LILRA2 , WWP1 , UBE2C , RAPGEF4 , BTN3A2 , BTN3A1 , BTN2A1 , CD160 , KIF3A , DCTN3 , KLHL2 , CD300A , SEC31A , UBOX5 , KLRK1 , KIFAP3 , TRIM32 , FBXO21 , PHLPP2 , RAP1GAP2 , TNRC6B , TAB2 , FBXL7 , PSME4 , PHLPP1 , FBXW11 , MGRN1 , UBR2 , ICOSLG , NEDD4L , UBR4 , UFL1 , PIP5K1C , SEC61G , LILRA4 , MKRN1 , LY96 , KIF4A , RASGRP3 , FBXO7 , HECTD1 , ANAPC13 , RNF19A , RCHY1 , LTN1 , DNM3 , HERC4 , WSB1 , KIF26A , FBXW2 , PTPN22 , FBXL21 , FBXL3 , FBXO2 , FBXL5 , FBXL4 , KLHL3 , FBXW8 , FBXO22 , FBXO10 , FBXO9 , FBXO6 , FBXO4 , FGF20 , AGO1 , FGF22 , SIGLEC7 , LAT , DAPP1 , AGO2 , SIGLEC9 , SIGLEC8 , RNF115 , KLHL20 , TNRC6A , UBE2S , TRAC , IGKV3D-11 , IGKV5-2 , IGKV4-1 , MYLIP , CLEC2D , CD274 , RACGAP1 , BLNK , ICOS , ANAPC2 , SEC61A1 , ANAPC4 , SH3KBP1 , CD209 , CD207 , TRAT1 , KLHL5 , SAR1B , ASB3 , RLIM , DYNC1LI1 , DCTN4 , HERC5 , MEX3C , FZR1 , KLRF1 , ANAPC5 , ANAPC7 , RNF138 , UBE2J1 , EVL , ANAPC11 , UBE2D4 , ASB1 , ASB4 , ASB2 , FBXO40 , ERAP1 , BTBD1 , TREM2 , TREM1 , FBXW5 , FBXL19 , RNF111 , FBXL12 , UBE2R2 , HERC6 , DET1 , KLHL11 , SEC61A2 , RNF220 , UBA6 , UBE2W , FBXW7 , FBXL8 , TRIM36 , UBE2Q1 , PRR5 , RNF126 , ENAH , RNF130 , PAG1 , RNF114 , KLHL9 , BTNL2 , CRTAM , TRIM39 , KIF15 , SMURF1 , HECW2 , HACE1 , KLHL42 , SH3RF1 , RNF213 , TNRC6C , TRIB3 , SLAMF7 , RNF123 , UBE2O , ERAP2 , PJA1 , MLST8 , RNF25 , KLHL25 , ANAPC1 , UNKL , SMURF2 , KLC2 , UBE2Z , MAPKAP1 , LILRA6 , FBXL15 , ULBP3 , HECTD3 , ASB13 , FBXO31 , PIP4K2C , TREML2 , UBA5 , BTNL8 , FBXL18 , SPSB1 , RNF34 , ORAI2 , ULBP1 , PDCD1LG2 , TRIM11 , KIF18A , RILP , ITCH , KBTBD7 , FBXO30 , TRAF7 , FBXW9 , AKT1S1 , CARD11 , DCTN5 , KBTBD8 , KIF2B , TRIM63 , LNX1 , SPSB2 , KLHL22 , ORAI1 , ZNRF1 , FBXL20 , TRIM4 , SIGLEC10 , SIGLEC12 , KBTBD6 , UBE3B , KLC4 , UBE3D , BTBD6 , KLHL13 , LRSAM1 , TRIM41 , LONRF1 , SPSB4 , ASB16 , UBE2Q2 , FBXO44 , TRIM9 , SIGLEC11 , TIRAP , SLAMF6 , OSBPL1A , FBXO32 , FBXO17 , THEM4 , SH2D1B , UBE2J2 , PIK3AP1 , JAML , PSMB11 , LRR1 , CD300LB , OSCAR , FBXO27 , ASB17 , RNF19B , AP1S3 , TRIM71 , CD200R1 , RAET1E , TRIM50 , ASB10 , ASB11 , ASB5 , ASB6 , ASB7 , ASB8 , ASB9 , TRIM69 , DYNLL2 , UBE2F , MIB2 , ASB15 , ASB14 , ASB12 , HECTD2 , PSMA8 , FBXL14 , NRG4 , FBXL16 , CD300LF , CD300LG , KLC3 , UBE2U , FBXO41 , DTX3L , BTLA , KLB , BTNL9 , RNF217 , KCTD7 , CBLL2 , AGO3 , AGO4 , UBR1 , KCTD6 , FBXO15 , TRIM39-RPP21 , RNF182 , FBXL13 , ZNRF2 , CDC26 , RICTOR , RNF144B , NCR3 , FBXL22 , FBXW12 , KIF4B , TREML4 , TREML1 , CD300E , LILRA5 , NCR3LG1 , KBTBD13 , ASB18 , C7orf76 , GLYCAM1 , NCF1 , CD300LD , MIR3620 , LOC100506136 , MICA , KLRC4-KLRK1 , MIR4720 , MIR4687 , MIR5196 , MIR5193 ,