description
The TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen presenting cells (APCs) results in the activation of protein tyrosine kinases (PTKs) that associate with CD3 and TCR zeta subunits and the co-receptor CD4. Members of the Src kinases (Lck), Syk kinases (ZAP-70), Tec (Itk) and Csk families of nonreceptor PTKs play a crucial role in T cell activation. Activation of PTKs following TCR engagement results in the recruitment and tyrosine phosphorylation of enzymes such as phospholipase C gamma1 and Vav as well as critical adaptor proteins such as LAT, SLP-76 and Gads. These proximal activation leads to reorganization of the cytoskeleton as well as transcription activation of multiple genes leading to T lymphocyte proliferation, differentiation and/or effector function

external resources
NCBI:1269172
REACTOME:R-HSA-202403
PUBMED:10375551
PUBMED:12876557
PUBMED:9989491

genes
CD3D , CD3E , CD3G , CD247 , CD4 , CDC34 , CHUK , CSK , FYB1 , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DQB2 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , IKBKB , INPP5D , ITK , LCK , LCP2 , NCK1 , NFKB1 , NFKBIA , PAK1 , PAK2 , PAK3 , PDPK1 , PIK3CA , PIK3CB , PIK3R1 , PIK3R2 , PLCG1 , PRKCQ , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTEN , PTPRC , PTPRJ , RELA , RPS27A , SKP1 , MAP3K7 , TRAF6 , UBA52 , UBB , UBC , UBE2D1 , UBE2D2 , UBE2N , UBE2V1 , VASP , WAS , ZAP70 , SEM1 , CUL1 , IKBKG , RIPK2 , BCL10 , BTRC , CD101 , GRAP2 , PSMF1 , PSMD6 , PSME3 , PSMD14 , MALT1 , TAB2 , PSME4 , FBXW11 , PTPN22 , LAT , TRAC , TRAT1 , EVL , ENAH , PAG1 , CARD11 , PSMB11 , PSMA8 , C7orf76 , LOC100506136 ,